Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab
Joint Authors
Karayannopoulou, Georgia
Zebekakis, Pantelis
Georgianos, Panagiotis I.
Vaios, Vasilios
Leontaridou, Eleni
Sioulis, Athanasios
Balaskas, Elias V.
Koletsa, Triantafyllia
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Immune-checkpoint-inhibitors (ICPIs) represent a novel class of immunotherapy against several malignancies.
These agents are associated with several “immune-mediated” adverse effects, but the reported renal toxicity of ICPIs is less well defined.
We present the case of a 60-year-old man with a history of non-small cell lung cancer, who developed acute kidney injury (AKI) approximately 3.5 months after initiation of immunotherapy with nivolumab.
Urinalysis revealed sterile pyuria, without microscopic hematuria or proteinuria.
Immunological examination was negative.
A renal biopsy showed severe interstitial inflammatory infiltration of T-cells, monocytes, and eosinophils without interstitial granulomas and normal appearance of glomeruli, indicating acute interstitial nephritis (AIN) as the cause of AKI.
After a short-term course of corticosteroids and permanent nivolumab discontinuation, partial recovery of renal function was noted.
AIN is a rare adverse effect of ICPIs that mandates the close monitoring of renal function in patients under immunotherapy with these agents.
American Psychological Association (APA)
Georgianos, Panagiotis I.& Vaios, Vasilios& Leontaridou, Eleni& Karayannopoulou, Georgia& Koletsa, Triantafyllia& Sioulis, Athanasios…[et al.]. 2019. Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab. Case Reports in Nephrology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1141084
Modern Language Association (MLA)
Georgianos, Panagiotis I.…[et al.]. Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab. Case Reports in Nephrology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1141084
American Medical Association (AMA)
Georgianos, Panagiotis I.& Vaios, Vasilios& Leontaridou, Eleni& Karayannopoulou, Georgia& Koletsa, Triantafyllia& Sioulis, Athanasios…[et al.]. Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab. Case Reports in Nephrology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1141084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141084