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Severe Hypocalcemia and Resulting Seizure Caused by Vitamin D Deficiency in an Older Patient Receiving Phenytoin: Eldecalcitol and Maxacalcitol Ointment as Potential Therapeutic Options for Hypocalcemia
Joint Authors
Aihara, Seishi
Yamada, Shunsuke
Kondo, Mika
Oka, Hideaki
Kamimura, Taro
Harada, Atsumi
Nakano, Toshiaki
Tsuruya, Kazuhiko
Kitazono, Takanari
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
An 82-year-old man treated with phenytoin for the prevention of symptomatic epilepsy was hospitalized to treat consciousness disturbance, seizure, and hypocalcemia (serum calcium: 4.6 mg/dL).
Serum 25-hydroxyvitamin D level was very low (5.4 ng/mL), whereas serum calcitriol level was normal (27 pg/mL) and serum intact parathyroid hormone level was increased (369 pg/mL).
He was finally diagnosed with vitamin D deficiency associated with low sunlight exposure and long-term phenytoin use for symptomatic epilepsy: phenytoin is shown to accelerate catabolism of 25-hydroxyvitamin D.
Combination treatment with eldecalcitol and maxacalcitol ointments successfully normalized corrected serum calcium level: both eldecalcitol and maxacalcitol are vitamin D receptor activators used for osteoporosis and psoriasis, respectively.
Our case illustrates the importance of periodic serum calcium level monitoring in patients receiving anti-epileptic drugs and the usefulness of eldecalcitol and maxacalcitol ointment as a therapeutic option for hypocalcemia, especially in countries where native vitamin D and 25-hydroxyvitamin D are not available.
American Psychological Association (APA)
Aihara, Seishi& Yamada, Shunsuke& Kondo, Mika& Oka, Hideaki& Kamimura, Taro& Harada, Atsumi…[et al.]. 2019. Severe Hypocalcemia and Resulting Seizure Caused by Vitamin D Deficiency in an Older Patient Receiving Phenytoin: Eldecalcitol and Maxacalcitol Ointment as Potential Therapeutic Options for Hypocalcemia. Case Reports in Nephrology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1141087
Modern Language Association (MLA)
Aihara, Seishi…[et al.]. Severe Hypocalcemia and Resulting Seizure Caused by Vitamin D Deficiency in an Older Patient Receiving Phenytoin: Eldecalcitol and Maxacalcitol Ointment as Potential Therapeutic Options for Hypocalcemia. Case Reports in Nephrology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1141087
American Medical Association (AMA)
Aihara, Seishi& Yamada, Shunsuke& Kondo, Mika& Oka, Hideaki& Kamimura, Taro& Harada, Atsumi…[et al.]. Severe Hypocalcemia and Resulting Seizure Caused by Vitamin D Deficiency in an Older Patient Receiving Phenytoin: Eldecalcitol and Maxacalcitol Ointment as Potential Therapeutic Options for Hypocalcemia. Case Reports in Nephrology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1141087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141087