Acute Kidney Injury Secondary to Necrotizing Sarcoid Granulomatosis
Joint Authors
Mamidi, Varun
Shekar, Manikantan
Chakola, Jaiju James
Makkena, Vamsi Krishna
Matcha, Jayakumar
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Sarcoidosis is a chronic disease characterized by noncaseating lesions involving any organ and tissue in the body.
Hypercalcemia and acute kidney injury is a common renal presentation of sarcoidosis.
Necrotizing sarcoid granulomatosis (NSG) is a granulomatous disease entity which presents with nodular masses of sarcoid like granuloma which primarily effects the lungs.
It is a rare necrotizing variant of sarcoidosis.
Extra pulmonary presentation of NSG is very rare.
Case presentation.
We present a 36-year-old female with hypercalcemia and acute kidney injury refractory to treatment.
Whole body Flourine-18-fluorodeoxyglucose positron emission tomography computed tomography (18F-FDG PET/CT) showed increased metabolic uptake with ill-defined lesions in the liver, spleen, and pelvic lymph nodes.
Biopsy of the ill-defined lesions in the liver showed necrotizing granulomatous lesions without angiitis.
All the markers of tuberculosis were negative and angiotensin converting enzyme levels were elevated.
Patient improved with 1 mg/kg/day oral steroid therapy and is on regular follow-up with minimal dose of steroids.
Conclusion.
Necrotizing sarcoid granulomatosis (NSG) is a rare systemic granulomatous disease.
Due to its rarity and diagnostic difficulty, treatment is challenging for clinicians, pathologists and radiologists.
Treatment of choice for symptomatic patients is steroid therapy.
Prognosis is good with complete recovery.
American Psychological Association (APA)
Mamidi, Varun& Shekar, Manikantan& Chakola, Jaiju James& Makkena, Vamsi Krishna& Matcha, Jayakumar. 2019. Acute Kidney Injury Secondary to Necrotizing Sarcoid Granulomatosis. Case Reports in Nephrology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1141095
Modern Language Association (MLA)
Mamidi, Varun…[et al.]. Acute Kidney Injury Secondary to Necrotizing Sarcoid Granulomatosis. Case Reports in Nephrology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1141095
American Medical Association (AMA)
Mamidi, Varun& Shekar, Manikantan& Chakola, Jaiju James& Makkena, Vamsi Krishna& Matcha, Jayakumar. Acute Kidney Injury Secondary to Necrotizing Sarcoid Granulomatosis. Case Reports in Nephrology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1141095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141095