Dorsoventral and Proximodistal Hippocampal Processing Account for the Influences of Sleep and Context on Memory (Re)consolidation: A Connectionist Model
Joint Authors
Fellous, Jean-Marc
Lines, Justin
Nation, Kelsey
Source
Computational Intelligence and Neuroscience
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-03
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The context in which learning occurs is sufficient to reconsolidate stored memories and neuronal reactivation may be crucial to memory consolidation during sleep.
The mechanisms of context-dependent and sleep-dependent memory (re)consolidation are unknown but involve the hippocampus.
We simulated memory (re)consolidation using a connectionist model of the hippocampus that explicitly accounted for its dorsoventral organization and for CA1 proximodistal processing.
Replicating human and rodent (re)consolidation studies yielded the following results.
(1) Semantic overlap between memory items and extraneous learning was necessary to explain experimental data and depended crucially on the recurrent networks of dorsal but not ventral CA3.
(2) Stimulus-free, sleep-induced internal reactivations of memory patterns produced heterogeneous recruitment of memory items and protected memories from subsequent interference.
These simulations further suggested that the decrease in memory resilience when subjects were not allowed to sleep following learning was primarily due to extraneous learning.
(3) Partial exposure to the learning context during simulated sleep (i.e., targeted memory reactivation) uniformly increased memory item reactivation and enhanced subsequent recall.
Altogether, these results show that the dorsoventral and proximodistal organization of the hippocampus may be important components of the neural mechanisms for context-based and sleep-based memory (re)consolidations.
American Psychological Association (APA)
Lines, Justin& Nation, Kelsey& Fellous, Jean-Marc. 2017. Dorsoventral and Proximodistal Hippocampal Processing Account for the Influences of Sleep and Context on Memory (Re)consolidation: A Connectionist Model. Computational Intelligence and Neuroscience،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1141138
Modern Language Association (MLA)
Lines, Justin…[et al.]. Dorsoventral and Proximodistal Hippocampal Processing Account for the Influences of Sleep and Context on Memory (Re)consolidation: A Connectionist Model. Computational Intelligence and Neuroscience No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1141138
American Medical Association (AMA)
Lines, Justin& Nation, Kelsey& Fellous, Jean-Marc. Dorsoventral and Proximodistal Hippocampal Processing Account for the Influences of Sleep and Context on Memory (Re)consolidation: A Connectionist Model. Computational Intelligence and Neuroscience. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1141138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141138