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Rapidly Progressive Glomerulonephritis Secondary to IgA Nephropathy in a Patient with Systemic Lupus Erythematosus
Joint Authors
Patel, Amol M.
Karam, Lily Anne Romero
Rojas, Stephanie C. Fuentes
Redfearn, Warren E.
Truong, Luan D.
Gonzalez, Juan M.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Lupus nephritis is a common manifestation of systemic lupus erythematosus (SLE).
IgA nephropathy is a common type of primary glomerulonephritis.
Renal manifestations in SLE patients are often due to lupus nephritis; however, renal diseases unrelated to lupus nephritis are rarely reported.
While crescentic IgA nephropathy with rapid clinical progression is rare, its development in patients with SLE in the absence of lupus nephritis is even more unusual.
A 74-year-old woman with a history of SLE without known renal involvement, chronic kidney disease stage IIIa, congestive heart failure, hypertension, and type 2 diabetes mellitus presented with acute kidney injury.
Her creatinine continued to rise rapidly.
Renal biopsy revealed mesangial proliferative glomerulonephritis with crescent formation.
Immunofluorescent staining showed IgA and C3 mesangial deposition and absence of C4 and C1q, consistent with IgA nephropathy.
She received a course of methylprednisolone and plasmapheresis.
Unfortunately, her renal function continued to deteriorate, and she was started on hemodialysis which was continued after hospital discharge.
This case illustrates crescentic IgA nephropathy without lupus nephritis as the cause of acute kidney injury in a patient with SLE.
It highlights the observation that renal diseases other than lupus nephritis can develop in SLE patients.
American Psychological Association (APA)
Patel, Amol M.& Karam, Lily Anne Romero& Rojas, Stephanie C. Fuentes& Redfearn, Warren E.& Truong, Luan D.& Gonzalez, Juan M.. 2019. Rapidly Progressive Glomerulonephritis Secondary to IgA Nephropathy in a Patient with Systemic Lupus Erythematosus. Case Reports in Nephrology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1141199
Modern Language Association (MLA)
Patel, Amol M.…[et al.]. Rapidly Progressive Glomerulonephritis Secondary to IgA Nephropathy in a Patient with Systemic Lupus Erythematosus. Case Reports in Nephrology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1141199
American Medical Association (AMA)
Patel, Amol M.& Karam, Lily Anne Romero& Rojas, Stephanie C. Fuentes& Redfearn, Warren E.& Truong, Luan D.& Gonzalez, Juan M.. Rapidly Progressive Glomerulonephritis Secondary to IgA Nephropathy in a Patient with Systemic Lupus Erythematosus. Case Reports in Nephrology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1141199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141199