Extraneural Metastasis of Primary Glioma Occurring in a Setting of Occupational Ionizing Radiation Exposure
Joint Authors
Prabhakaran, Nitya
Frazier, Shellaine R.
Litofsky, N. Scott
Miller, Douglas C.
Source
Case Reports in Neurological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Malignant gliomas account for 60% of all primary brain tumors in adults.
Glioblastoma Multiforme (GBM) is the most common primary glial tumor with a dismal prognosis and a median survival of approximately 14 months.
Extra-neural metastases from primary brain tumors are unusual with an incidence rate of less than 2%.
This has been attributed to factors such as short survival, lack of true lymphatics in the CNS, and physical barriers provided by the dura, extracellular matrix, and basement membrane.
Although most GBMs occur sporadically, there is a known association with therapeutic radiation exposure and with work in nuclear disaster cleanup.
To our knowledge, no case of GBM with metastasis occurring in a patient with occupational radiation exposure currently exists in the literature.
In this article, we present a case of GBM with lung metastasis occurring in a 51-year-old Caucasian male, whose history is significant for occupational exposure to ionizing radiation, and review the literature on GBM risk factors and potential mechanisms of metastasis.
American Psychological Association (APA)
Prabhakaran, Nitya& Miller, Douglas C.& Litofsky, N. Scott& Frazier, Shellaine R.. 2019. Extraneural Metastasis of Primary Glioma Occurring in a Setting of Occupational Ionizing Radiation Exposure. Case Reports in Neurological Medicine،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1141270
Modern Language Association (MLA)
Prabhakaran, Nitya…[et al.]. Extraneural Metastasis of Primary Glioma Occurring in a Setting of Occupational Ionizing Radiation Exposure. Case Reports in Neurological Medicine No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1141270
American Medical Association (AMA)
Prabhakaran, Nitya& Miller, Douglas C.& Litofsky, N. Scott& Frazier, Shellaine R.. Extraneural Metastasis of Primary Glioma Occurring in a Setting of Occupational Ionizing Radiation Exposure. Case Reports in Neurological Medicine. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1141270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141270