Choice of Allograft in Patients Requiring Intestinal Transplantation: A Critical Review
Joint Authors
Huard, Geneviève
Schiano, Thomas D.
Moon, Jang
Iyer, Kishore
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Intestinal transplantation (ITx) is indicated in patients with irreversible intestinal failure (IF) and life-threatening complications related to total parenteral nutrition (TPN).
ITx can be classified into three main types.
Isolated intestinal transplantation (IITx), that is, transplantation of the jejunoileum, is indicated in patients with preserved liver function.
Combined liver-intestine transplantation (L-ITx), that is, transplantation of the liver and the jejunoileum, is indicated in patients with liver failure related to TPN.
Thus, patients with cirrhosis or advanced fibrosis should receive a combined allograft, while patients with lower grades of liver fibrosis can usually safely undergo ITx.
Reflecting their degree of sickness, the waitlist mortality rate and the early posttransplant outcomes of patients receiving L-ITx are worse than IITx.
However, L-ITx is associated with better long-term graft and patient survival.
Multivisceral transplantation (MVTx), that is, transplantation of the organs dependent on the celiac axis and superior mesenteric artery, can be classified into full MVTx if it includes the liver and modified MVTx if it does not.
The most common indications for MVTx are extensive portomesenteric thrombosis and diffuse gastrointestinal pathology such as motility disorders and polyposis syndrome.
Every patient with IF should undergo a multidisciplinary evaluation by an experienced ITx team.
American Psychological Association (APA)
Huard, Geneviève& Schiano, Thomas D.& Moon, Jang& Iyer, Kishore. 2017. Choice of Allograft in Patients Requiring Intestinal Transplantation: A Critical Review. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141334
Modern Language Association (MLA)
Huard, Geneviève…[et al.]. Choice of Allograft in Patients Requiring Intestinal Transplantation: A Critical Review. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1141334
American Medical Association (AMA)
Huard, Geneviève& Schiano, Thomas D.& Moon, Jang& Iyer, Kishore. Choice of Allograft in Patients Requiring Intestinal Transplantation: A Critical Review. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141334