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Advanced Hepatic Fibrosis in Fatty Liver Disease Linked to Hyperplastic Colonic Polyp
Joint Authors
Nseir, William
Mahamid, Mahmud
Abu-Elhija, Omar
Yassin, Tarik
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
Our study aims to determine possible association between biopsy-proven nonalcoholic steatohepatitis (NASH) and hyperplastic polyps (HP) of the colon.
Methods.
A retrospective cohort observational study.
All subjects underwent screening colonoscopy within two years.
Data were extracted from the patient charts including demographic, anthropometric measurement, vital signs, underlying diseases, medical therapy, laboratory data, results of the liver biopsy with degree of fibrosis and necroinflammatory activity, the colonoscopy report, and the pathological report of the extracted polyp.
Results.
A total of 223 patients were included in our study, 123 patients with biopsy-proven NASH and 100 patients without NASH who served as the control group matched for age.
14 colonic adenomas (11% of patients) were found in the NASH group compared with 16 adenomas (16% of patients) found in the control group (P=0.9).
28 HPs were found in the NASH group (22.7%) compared with only 8 HPs in the control group (8%) (P<0.05).
21 from the 28 (75%) HPs diagnosed in the NASH group were observed in the high degree fibrosis patients (Fibrosis Stages 3 and 4), 6 HPs (21%) were associated with Fibrosis Stages 1 and 2, and single HP (4%) was associated with Fibrosis Stage 0.
Conclusions.
Our study showed an association between biopsy-proven steatohepatitis and the burden of hyperplastic polyp.
The severity of hepatic fibrosis may play important role in the increased occurrence of HPs.
American Psychological Association (APA)
Mahamid, Mahmud& Abu-Elhija, Omar& Yassin, Tarik& Nseir, William. 2017. Advanced Hepatic Fibrosis in Fatty Liver Disease Linked to Hyperplastic Colonic Polyp. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1141355
Modern Language Association (MLA)
Mahamid, Mahmud…[et al.]. Advanced Hepatic Fibrosis in Fatty Liver Disease Linked to Hyperplastic Colonic Polyp. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1141355
American Medical Association (AMA)
Mahamid, Mahmud& Abu-Elhija, Omar& Yassin, Tarik& Nseir, William. Advanced Hepatic Fibrosis in Fatty Liver Disease Linked to Hyperplastic Colonic Polyp. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1141355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141355