Bone Loss Prevention of Bisphosphonates in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Joint Authors
Hu, Yan
Chen, Xiaoting
Chen, Xiaojing
Zhang, Shuang
Jiang, Tianyan
Chang, Jing
Gao, Yanhong
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
The purpose of this study was to evaluate the effect of bisphosphonates in improving bone mineral density (BMD) and decreasing the occurrence rate of fractures and adverse events in patients with inflammatory bowel disease (IBD).
Methods.
Randomized controlled trials (RCTs) which use bisphosphonates in IBD patients were identified in PubMed, MEDLINE database, EMBASE database, Web of Knowledge, and the Cochrane Databases between 1990 and June 2016.
People received bisphosphonate or placebos with a follow-up of at least one year were also considered.
STATA 12.0 software was used for the meta-analysis.
Results.
Eleven randomized clinical trials were included in the meta-analysis.
The data indicated that the percentage change in the increased BMD in the bisphosphonates groups was superior to that of the control groups at the lumbar spine and total hip.
At the femoral neck, there was no significant difference between the two groups.
The incidence of new fractures during follow-up showed significant reduction.
The adverse event analysis revealed no significant difference between the two groups.
Conclusion.
Our results demonstrate that bisphosphonates therapy has an effect on bone loss in patients with IBD but show no evident efficiency at increasing the incidence of adverse events.
American Psychological Association (APA)
Hu, Yan& Chen, Xiaoting& Chen, Xiaojing& Zhang, Shuang& Jiang, Tianyan& Chang, Jing…[et al.]. 2017. Bone Loss Prevention of Bisphosphonates in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1141365
Modern Language Association (MLA)
Hu, Yan…[et al.]. Bone Loss Prevention of Bisphosphonates in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1141365
American Medical Association (AMA)
Hu, Yan& Chen, Xiaoting& Chen, Xiaojing& Zhang, Shuang& Jiang, Tianyan& Chang, Jing…[et al.]. Bone Loss Prevention of Bisphosphonates in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1141365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141365