Possible Involvement of Liver Resident Macrophages (Kupffer Cells) in the Pathogenesis of Both Intrahepatic and Extrahepatic Inflammation
Joint Authors
Kakinuma, Yuki
Kimura, Takuya
Watanabe, Yoshifumi
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Liver resident macrophages designated Kupffer cells (KCs) form the largest subpopulation of tissue macrophages.
KCs are involved in the pathogenesis of liver inflammation.
However, the role of KCs in the systemic inflammation is still elusive.
In this study, we examined whether KCs are involved in not only intrahepatic inflammation but also extrahepatic systemic inflammation.
Administration of clodronate liposomes resulted in the KC deletion and in the suppression of liver injury in T cell-mediated hepatitis by ConA as a local acute inflammation model, while the treatment did not influence dextran sulfate sodium- (DSS-) induced colitis featured by weight loss, intestinal shrink, and pathological observation as an ectopic local acute inflammation model.
In contrast, KC deletion inhibited collagen-induced arthritis as a model of extrahepatic, systemic chronical inflammation.
KC deleted mice showed weaker arthritic scores, less joint swelling, and more joint space compared to arthritis-induced control mice.
These results strongly suggest that KCs are involved in not only intrahepatic inflammatory response but also systemic (especially) chronic inflammation.
American Psychological Association (APA)
Kakinuma, Yuki& Kimura, Takuya& Watanabe, Yoshifumi. 2017. Possible Involvement of Liver Resident Macrophages (Kupffer Cells) in the Pathogenesis of Both Intrahepatic and Extrahepatic Inflammation. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141369
Modern Language Association (MLA)
Kakinuma, Yuki…[et al.]. Possible Involvement of Liver Resident Macrophages (Kupffer Cells) in the Pathogenesis of Both Intrahepatic and Extrahepatic Inflammation. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1141369
American Medical Association (AMA)
Kakinuma, Yuki& Kimura, Takuya& Watanabe, Yoshifumi. Possible Involvement of Liver Resident Macrophages (Kupffer Cells) in the Pathogenesis of Both Intrahepatic and Extrahepatic Inflammation. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141369