Epileptic Patient with Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy (MOGHE): A Case Report and Review of the Literature
Joint Authors
Patrikelis, Panayiotis
Alexoudi, Athanasia
Korfias, Stefanos
Verentzioti, A.
Blumcke, I.
Sakas, D.
Siatouni, Anna
Gatzonis, Stylianos
Source
Case Reports in Neurological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
There is an emerging interest in the literature about MOGHE (Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy).
We report the case of an epileptic patient with MOGHE.
Case Report.
A 33-year-old male patient was suffering from refractory focal epilepsy since adolescence.
MRI demonstrated increased T2/FLAIR signal intensity of right frontal lobe.
Presurgical evaluation led to definition of epileptogenic network in a specific area of right frontal lobe.
The resected specimen revealed MOGHE.
Discussion.
MOGHE appears to be a brain entity which shares some unique histopathological features.
Review of the literature is in accordance with our patient’s findings.
The major neuropathological finding consists of areas with blurred gray-white matter boundaries due to heterotopic neurons in white matter and increased numbers of subcortical oligodendroglial cells with increased proliferation.
MR abnormalities are present in T2/FLAIR sequences.
It concerns patients with refractory frontal lobe epilepsy and appears to associate with unfavourable postsurgical outcome in seizure control.
Conclusion.
More cases are needed in order to establish more data about this distinct entity in frontal lobe epilepsy.
This could be valuable knowledge to patients and doctors concerning expectations or management of undesirable outcome in frontal lobe epilepsy surgery.
American Psychological Association (APA)
Verentzioti, A.& Blumcke, I.& Alexoudi, Athanasia& Patrikelis, Panayiotis& Siatouni, Anna& Korfias, Stefanos…[et al.]. 2019. Epileptic Patient with Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy (MOGHE): A Case Report and Review of the Literature. Case Reports in Neurological Medicine،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1141399
Modern Language Association (MLA)
Verentzioti, A.…[et al.]. Epileptic Patient with Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy (MOGHE): A Case Report and Review of the Literature. Case Reports in Neurological Medicine No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1141399
American Medical Association (AMA)
Verentzioti, A.& Blumcke, I.& Alexoudi, Athanasia& Patrikelis, Panayiotis& Siatouni, Anna& Korfias, Stefanos…[et al.]. Epileptic Patient with Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy (MOGHE): A Case Report and Review of the Literature. Case Reports in Neurological Medicine. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1141399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141399