Utility of Botulinum Injections in Stiff-Person Syndrome
Joint Authors
Conners, L. M.
Betcher, A.
Shahinian, A.
Janda, P.
Source
Case Reports in Neurological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-07
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Stiff-person syndrome (SPS) is an uncommon neurological disorder characterized by significant rigidity and muscle spasms primarily affecting the truncal and proximal musculature.
Furthermore, a wide-based gait with functional impairment is generally seen.
High-dose benzodiazepines or baclofen are widely considered the optimal initial therapy; however, major adverse effects often preclude adequate dosing.
Refractory cases may be treated with intravenous immunoglobulins (IVIG), plasma exchange, or B-cell depletion with rituximab, although these are also associated with major, sometimes fatal, adverse reactions.
Several reports have validated the safety and utility of botulinum injections in this setting, yet botulinum remains markedly underutilized in this cohort.
Below, a case report and review of the literature show botulinum can decrease pain and stiffness, improve gait and balance, and decrease dependence on powerful systemic treatments in this group.
American Psychological Association (APA)
Conners, L. M.& Betcher, A.& Shahinian, A.& Janda, P.. 2019. Utility of Botulinum Injections in Stiff-Person Syndrome. Case Reports in Neurological Medicine،Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1141416
Modern Language Association (MLA)
Conners, L. M.…[et al.]. Utility of Botulinum Injections in Stiff-Person Syndrome. Case Reports in Neurological Medicine No. 2019 (2019), pp.1-3.
https://search.emarefa.net/detail/BIM-1141416
American Medical Association (AMA)
Conners, L. M.& Betcher, A.& Shahinian, A.& Janda, P.. Utility of Botulinum Injections in Stiff-Person Syndrome. Case Reports in Neurological Medicine. 2019. Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1141416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141416