A Case of Carbon Monoxide-Induced Delayed Neurological Sequelae Successfully Treated with Hyperbaric Oxygen Therapy, N-Acetylcysteine, and Glucocorticoids: Clinical and Neuroimaging Follow-Up
Joint Authors
Bonfiglio, Luca
Spina, Vincenzo
Tomaiuolo, Francesco
Celli, Lorenzo
Cecchetti, Luca
Carboncini, Maria Chiara
Source
Case Reports in Neurological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Carbon monoxide (CO) poisoning is a leading cause of intentional and unintentional poisoning worldwide, associated with mortality and severe morbidity.
Some survivors of CO poisoning develop, after a lucid interval, a potentially permanent encephalopathy in the form of cognitive impairment and movement disorders, such as Parkinsonism.
One of the most frequent neuroimaging findings is a cerebral white matter damage, but so far its precise cause and specific therapy are still debated.
We here report the case of a 33-year-old woman with severe carbon monoxide poisoning who, after a period of lucid interval, presented symptoms of declining motor and cognitive functions.
She was treated with 40 sessions of Hyperbaric Oxygen Therapy (HBOT).
The therapeutic use of oxygen at supraphysiological pressures might either increase systemic oxidative stress or cause an overproduction of oxygen free radicals as drawbacks.
Concurrent use of antioxidants and anti-inflammatory drugs may prevent the side effects of oxygen therapy at supraphysiological pressure due to oxidative stress.
For this reason, the patient was also treated with high-dose N-Acetylcysteine and glucocorticoids.
Here, we describe the longitudinal monitoring of patient’s cognitive abilities and leukoencephalopathy associated with her positive clinical outcome.
American Psychological Association (APA)
Spina, Vincenzo& Tomaiuolo, Francesco& Celli, Lorenzo& Bonfiglio, Luca& Cecchetti, Luca& Carboncini, Maria Chiara. 2019. A Case of Carbon Monoxide-Induced Delayed Neurological Sequelae Successfully Treated with Hyperbaric Oxygen Therapy, N-Acetylcysteine, and Glucocorticoids: Clinical and Neuroimaging Follow-Up. Case Reports in Neurological Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1141418
Modern Language Association (MLA)
Spina, Vincenzo…[et al.]. A Case of Carbon Monoxide-Induced Delayed Neurological Sequelae Successfully Treated with Hyperbaric Oxygen Therapy, N-Acetylcysteine, and Glucocorticoids: Clinical and Neuroimaging Follow-Up. Case Reports in Neurological Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1141418
American Medical Association (AMA)
Spina, Vincenzo& Tomaiuolo, Francesco& Celli, Lorenzo& Bonfiglio, Luca& Cecchetti, Luca& Carboncini, Maria Chiara. A Case of Carbon Monoxide-Induced Delayed Neurological Sequelae Successfully Treated with Hyperbaric Oxygen Therapy, N-Acetylcysteine, and Glucocorticoids: Clinical and Neuroimaging Follow-Up. Case Reports in Neurological Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1141418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141418