Prevalence and Anatomic Distribution of Serrated and Adenomatous Lesions in Patients with Inflammatory Bowel Disease
Joint Authors
Ghosh, Subrata
Lee, Lik Hang
Iacucci, Marietta
Fort Gasia, Miriam
Urbanski, Stefan
Panaccione, Remo
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Sessile serrated adenomas/polyps (SSA/Ps) and traditional serrated adenomas (TSAs) have not been well characterized in patients with inflammatory bowel disease (IBD).
This study assesses the prevalence and anatomic distribution of SSA/Ps, TSAs, and conventional adenomas/dysplasia (Ad/Ds) in IBD patients.
Methods.
IBD patients with serrated, adenomatous, or hyperplastic lesions between 2005 and 2009 were identified in the regional tertiary-care hospital database.
Clinicopathological information was reviewed and the histology of biopsies was reevaluated.
Results.
Ninety-six Ad/Ds, 25 SSA/Ps, and 4 TSAs were identified in 83 patients.
Compared to Ad/Ds, serrated lesions were more prevalent in females (p=0.046).
The prevalence of Ad/Ds was 4.95%, SSA/Ps was 1.39%, and TSAs was 0.31%.
No relationship was identified between lesion type and IBD type.
Comparing all IBD patients, the distribution of lesion types was significantly different (p=0.02) with Ad/Ds more common distally, SSA/Ps more common proximally, and TSAs evenly distributed.
Among Crohn’s disease (CD) patients, a similar distribution difference was noted (p<0.001).
However, ulcerative colitis (UC) patients had a uniform distribution of lesion types (p=0.320).
Conclusions.
IBD patients have a lower prevalence of premalignant lesions compared to the general population, and the anatomic distribution of lesions differed between CD and UC patients.
These findings may indicate an interaction between lesion and IBD pathogenesis with potential clinical implications.
American Psychological Association (APA)
Lee, Lik Hang& Iacucci, Marietta& Fort Gasia, Miriam& Ghosh, Subrata& Panaccione, Remo& Urbanski, Stefan. 2017. Prevalence and Anatomic Distribution of Serrated and Adenomatous Lesions in Patients with Inflammatory Bowel Disease. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141437
Modern Language Association (MLA)
Lee, Lik Hang…[et al.]. Prevalence and Anatomic Distribution of Serrated and Adenomatous Lesions in Patients with Inflammatory Bowel Disease. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1141437
American Medical Association (AMA)
Lee, Lik Hang& Iacucci, Marietta& Fort Gasia, Miriam& Ghosh, Subrata& Panaccione, Remo& Urbanski, Stefan. Prevalence and Anatomic Distribution of Serrated and Adenomatous Lesions in Patients with Inflammatory Bowel Disease. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141437