Exploration of Superior Modality: Safety and Efficacy of Hypofractioned Image-Guided Intensity Modulated Radiation Therapy in Patients with Unresectable but Confined Intrahepatic Hepatocellular Carcinoma
Joint Authors
Yang, Ping
Jiang, Tao
Hu, Yong
Zeng, Zhao-chong
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To evaluate the efficacy and safety of hypofractioned image-guided intensity modulated radiation therapy (IG-IMRT) for unresectable but confined intrahepatic hepatocellular carcinoma in comparison with conventional 3-dimensional conformal radiotherapy (3D-CRT).
Methods.
Ninety patients with unresectable but confined intrahepatic hepatocellular carcinoma without distant metastasis and tumor thrombosis received external beam radiation therapy.
Of these patients, 45 received IG-IMRT and 45 received 3D-CRT.
The IG-IMRT design delivered a median total hypofractionated dose of 54 Gy (2.2–5.5 Gy/fx), and 3D-CRT delivered a median total dose of 54 Gy with a conventional fraction (2.0 Gy/fx).
The clinical response, overall survival, and side effects were analyzed.
Results.
The IG-IMRT group showed significantly higher 1-year survival (93.3 versus 77.8%) and 2-year survival (73.3 versus 51.1%) and longer median survival (44.7 versus 24.0 months) than the 3D-CRT group.
Multivariate analysis indicated that the patients with intrahepatic tumors smaller than 8 cm, prior TACE before RT, and IG-IMRT would have a survival benefit.
There were no significant differences in the rates of side effects between the two groups.
Conclusion.
Hypofractioned IG-IMRT could improve the therapeutic response and confer a potential survival of patients with unresectable but confined intrahepatic hepatocellular carcinoma compared to 3D-CRT with acceptable toxicity.
American Psychological Association (APA)
Jiang, Tao& Zeng, Zhao-chong& Yang, Ping& Hu, Yong. 2017. Exploration of Superior Modality: Safety and Efficacy of Hypofractioned Image-Guided Intensity Modulated Radiation Therapy in Patients with Unresectable but Confined Intrahepatic Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141449
Modern Language Association (MLA)
Jiang, Tao…[et al.]. Exploration of Superior Modality: Safety and Efficacy of Hypofractioned Image-Guided Intensity Modulated Radiation Therapy in Patients with Unresectable but Confined Intrahepatic Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1141449
American Medical Association (AMA)
Jiang, Tao& Zeng, Zhao-chong& Yang, Ping& Hu, Yong. Exploration of Superior Modality: Safety and Efficacy of Hypofractioned Image-Guided Intensity Modulated Radiation Therapy in Patients with Unresectable but Confined Intrahepatic Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141449