Prognostic Impact of Cirrhosis in Patients with Intrahepatic Cholangiocarcinoma following Hepatic Resection
Joint Authors
Jeong, Seogsong
Gao, Lei
Tong, Ying
Xia, Lei
Xu, Ning
Sha, Meng
Zhang, Jianjun
Kong, Xiaoni
Gu, Jinyang
Xia, Qiang
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Prognostic impact of cirrhosis in patients with intrahepatic cholangiocarcinoma (ICC) upon hepatic resection remains unclear due to lack of studies in the literature.
Methods.
A total of 106 resected patients with ICC were reviewed, including 25 patients (23.6%) with cirrhosis and 81 noncirrhotic patients (76.4%).
Subgroups of cirrhotic patients with and without hepatitis B virus (HBV) infection were studied.
Results.
The impact of cirrhosis on the overall survival (OS) (hazard ratio [HR], 0.901; 95% confidence interval [CI], 0.510 to 1.592; P=0.720) and the relapse-free survival (RFS) (HR, 0.889; 95% CI, 0.509 to 1.552; P=0.678) revealed no statistical significance.
Furthermore, HBV-associated cirrhotic patients and the other cirrhotic patients demonstrated no statistical difference on survival outcomes (1 yr OS, 60.0% versus 70.0%; 5 yr OS, 10.0% versus 0%; P=0.744; 1 yr RFS, 53.3% versus 30.0%; 5 yr RFS, 10.0% versus 0%; P=0.279).
In patients with cirrhosis, tumor size larger than 5 cm was found to be the foremost factor that was independently associated with poor prognosis.
Conclusion.
The presence of liver cirrhosis did not significantly affect prognosis of patients with ICC after resection.
Downstaging modality may be in need for patients with ICC underlying cirrhosis, which remains to be validated in future studies.
American Psychological Association (APA)
Jeong, Seogsong& Gao, Lei& Tong, Ying& Xia, Lei& Xu, Ning& Sha, Meng…[et al.]. 2017. Prognostic Impact of Cirrhosis in Patients with Intrahepatic Cholangiocarcinoma following Hepatic Resection. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1141455
Modern Language Association (MLA)
Jeong, Seogsong…[et al.]. Prognostic Impact of Cirrhosis in Patients with Intrahepatic Cholangiocarcinoma following Hepatic Resection. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1141455
American Medical Association (AMA)
Jeong, Seogsong& Gao, Lei& Tong, Ying& Xia, Lei& Xu, Ning& Sha, Meng…[et al.]. Prognostic Impact of Cirrhosis in Patients with Intrahepatic Cholangiocarcinoma following Hepatic Resection. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1141455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141455