Pregnancy Outcome after Exposure to Migalastat for Fabry Disease: A Clinical Report
Joint Authors
Prohászka, Zoltán
Haninger-Vacariu, Natalja
El-Hadi, Sarah
Pauler, Udo
Foretnik, Marina
Schmidt, Alice
Skuban, Nina
Barth, Jay A.
Sunder-Plassmann, Gere
Kain, Renate
Source
Case Reports in Obstetrics and Gynecology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Our patient was a 37-year-old woman with Fabry disease (GLA p.R112H) with a medical history of recurrent headache, nausea, vomiting, vertigo, and tobacco use (20 cigarettes/day).
Fabry disease was diagnosed in 2005 when she experienced proteinuria, preeclampsia, and hypertension (201/130 mm Hg) during pregnancy (delivered 50 cm, 3.4 kg healthy boy; GLA wild type [WT]).
Enzyme replacement therapy was initiated in 2009.
The patient enrolled in the phase 3 ATTRACT trial (ClinicalTrials.gov; NCT01218659) and started migalastat in May 2012 while taking hormonal contraceptives.
Two years after initiating migalastat, the patient had proteinuria (2166 mg/24 h) without hypertension (131/68 mm Hg), which persisted (788 mg/24 h a month later).
Kidney biopsy results were consistent with existing Fabry disease.
A serum pregnancy test and ultrasound confirmed pregnancy (18 weeks’ gestation).
Migalastat and hormonal contraceptives were stopped; the patient continued to smoke.
Fetal MRI was normal at ~29 weeks’ gestation.
In October 2014, at 37+ weeks’ gestation, the patient delivered a 45-cm, 2.29-kg healthy girl (GLA WT).
Excepting low birth weight, which may be related to the patient’s smoking, pregnancy outcome was normal despite exposure to migalastat for 18 weeks.
Migalastat therapy during pregnancy is not advised.
American Psychological Association (APA)
Haninger-Vacariu, Natalja& El-Hadi, Sarah& Pauler, Udo& Foretnik, Marina& Kain, Renate& Prohászka, Zoltán…[et al.]. 2019. Pregnancy Outcome after Exposure to Migalastat for Fabry Disease: A Clinical Report. Case Reports in Obstetrics and Gynecology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1141466
Modern Language Association (MLA)
Haninger-Vacariu, Natalja…[et al.]. Pregnancy Outcome after Exposure to Migalastat for Fabry Disease: A Clinical Report. Case Reports in Obstetrics and Gynecology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1141466
American Medical Association (AMA)
Haninger-Vacariu, Natalja& El-Hadi, Sarah& Pauler, Udo& Foretnik, Marina& Kain, Renate& Prohászka, Zoltán…[et al.]. Pregnancy Outcome after Exposure to Migalastat for Fabry Disease: A Clinical Report. Case Reports in Obstetrics and Gynecology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1141466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141466