Grazoprevir and Elbasvir in Patients with Genotype 1 Hepatitis C Virus Infection: A Comprehensive Efficacy and Safety Analysis
Joint Authors
Li, Jun
Yao, Yinan
Yue, Ming
Wang, Jie
Chen, Hongbo
Liu, Mei
Zang, Feng
Zhang, Yun
Huang, Peng
Yu, Rongbin
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
It is urgent for patients with hepatitis C virus (HCV) infection to find a safe, effective, and interferon-free regimen to optimize therapy.
A comprehensive analysis was performed to evaluate the efficacy and safety of the grazoprevir combined with elbasvir, with or without ribavirin (RBV), in 777 treatment-naive and treatment-experienced patients with HCV genotype 1 infection from 3 randomized controlled trials (RCTs).
Method.
We collected data from the following trials: C-WORTHY (NCT01717326), C-SALVAGE (NCT02105454), and C-EDGE (NCT02105467).
All patients received grazoprevir plus elbasvir with or without RBV for 12 or 18 weeks.
The sustained virological response (SVR) 12 weeks after end of treatment was calculated for overall and subgroups.
Results.
568 (73%) patients were treatment-naive.
Overall, 95% (95% CI: 93–96) patients achieved SVR12, 95% (95% CI: 92–96) for treatment-naive and 96% (95% CI: 92–98) for previously treated patients, respectively.
Treatment duration and treatment regimen did not have great difference in SVR12 rates.
The most common AEs were fatigue (18%–29%), headache (20%), nausea (8%–14%), and asthenia (4%–12%).
One patient (<1%) receiving grazoprevir plus elbasvir alone and one (<1%) receiving grazoprevir plus elbasvir plus RBV had treatment-related serious AEs.
Conclusions.
The result shows that 12-week grazoprevir plus elbasvir therapy is safe and effective for treatment-naive patients with HCV genotype 1.
American Psychological Association (APA)
Yao, Yinan& Yue, Ming& Wang, Jie& Chen, Hongbo& Liu, Mei& Zang, Feng…[et al.]. 2017. Grazoprevir and Elbasvir in Patients with Genotype 1 Hepatitis C Virus Infection: A Comprehensive Efficacy and Safety Analysis. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1141477
Modern Language Association (MLA)
Yao, Yinan…[et al.]. Grazoprevir and Elbasvir in Patients with Genotype 1 Hepatitis C Virus Infection: A Comprehensive Efficacy and Safety Analysis. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1141477
American Medical Association (AMA)
Yao, Yinan& Yue, Ming& Wang, Jie& Chen, Hongbo& Liu, Mei& Zang, Feng…[et al.]. Grazoprevir and Elbasvir in Patients with Genotype 1 Hepatitis C Virus Infection: A Comprehensive Efficacy and Safety Analysis. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1141477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141477