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Recognition of Lynch Syndrome Amongst Newly Diagnosed Colorectal Cancers at St. Paul’s Hospital
Joint Authors
Enns, Robert
Nap-Hill, Estello
Telford, Jennifer J.
Pi, Steven
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Lynch Syndrome (LS) is the most common cause of inherited colorectal cancer (CRC).
In British Columbia, most centres still use clinical criteria (Amsterdam II, Revised Bethesda, or the BC Cancer Agency’s criteria) to determine who should undergo further first-line testing in the form of microsatellite instability or immunohistochemistry staining.
Given the limitations with this strategy, LS is thought to be underrecognized.
Objective.
To investigate whether LS is truly underrecognized when compared to the reported prevalence.
Methods.
A retrospective chart review of all CRC cases diagnosed at St.
Paul’s Hospital from 2010 to 2013 was conducted.
Results.
246 patients met inclusion criteria.
76% (83/109) with a family history of malignancy were unable to recall the specific malignancy or age of diagnosis.
18% (43/235) were only asked about a history of gastrointestinal related malignancy and 26% (65/246) met at least one of the three criteria but only 21% (13/63) received further investigation.
Only 1.6% (4/246) had LS compared to the reported prevalence of 2–5% of all CRC cases.
Conclusion.
This data supports our hypothesis that LS is underrecognized.
Issues at the patient, physician, and systems level need to be evaluated to determine where the limitations preventing appropriate testing are occurring.
American Psychological Association (APA)
Pi, Steven& Nap-Hill, Estello& Telford, Jennifer J.& Enns, Robert. 2017. Recognition of Lynch Syndrome Amongst Newly Diagnosed Colorectal Cancers at St. Paul’s Hospital. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1141503
Modern Language Association (MLA)
Pi, Steven…[et al.]. Recognition of Lynch Syndrome Amongst Newly Diagnosed Colorectal Cancers at St. Paul’s Hospital. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1141503
American Medical Association (AMA)
Pi, Steven& Nap-Hill, Estello& Telford, Jennifer J.& Enns, Robert. Recognition of Lynch Syndrome Amongst Newly Diagnosed Colorectal Cancers at St. Paul’s Hospital. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1141503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141503