Evidences of the Low Implication of Mosquitoes in the Transmission of Mycobacterium ulcerans, the Causative Agent of Buruli Ulcer
Joint Authors
Elise Solange, Kakou-N'Gazoa
Mbacham, Wilfred F.
Tamo, M.
Zeukeng, Francis
Bigoga, Jude D.
Djouaka, Rousseau
N’golo Coulibaly, David
Tchigossou, Genevieve
Akoton, Romaric
Aboubacar, Sylla
Tchebe, Sodjinin Jean-Eudes
Nantcho Nguepdjo, Clavella
Adeoti, Razack
Djegbe, Innocent
Ablordey, Anthony
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Buruli ulcer (BU) continues to be a serious public health threat in wet tropical regions and the mode of transmission of its etiological agent, Mycobacterium ulcerans (MU), remains poorly understood.
In this study, mosquito species collected in endemic villages in Benin were screened for the presence of MU.
In addition, the ability of mosquitoes larvae to pick up MU from their environment and remain colonized through the larval developmental stages to the adult stage was investigated.
Methods.
7,218 adults and larvae mosquitoes were sampled from endemic and nonendemic villages and screened for MU DNA targets (IS2404, IS2606, and KR-B) using qPCR.
Results.
MU was not detected in any of the field collected samples.
Additional studies of artificially infected larvae of Anopheles kisumu with MU strains revealed that mosquitoes larvae are able to ingest and host MU during L1, L2, L3, and L4 developmental stages.
However, we noticed an absence of these bacteria at both pupae and adult stages, certainly revealing the low ability of infected or colonized mosquitoes to vertically transmit MU to their offspring.
Conclusion.
The overall findings highlight the low implication of mosquitoes as biological vectors in the transmission cycle of MU from the risk environments to humans.
American Psychological Association (APA)
Djouaka, Rousseau& Zeukeng, Francis& Bigoga, Jude D.& N’golo Coulibaly, David& Tchigossou, Genevieve& Akoton, Romaric…[et al.]. 2017. Evidences of the Low Implication of Mosquitoes in the Transmission of Mycobacterium ulcerans, the Causative Agent of Buruli Ulcer. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1141522
Modern Language Association (MLA)
Djouaka, Rousseau…[et al.]. Evidences of the Low Implication of Mosquitoes in the Transmission of Mycobacterium ulcerans, the Causative Agent of Buruli Ulcer. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1141522
American Medical Association (AMA)
Djouaka, Rousseau& Zeukeng, Francis& Bigoga, Jude D.& N’golo Coulibaly, David& Tchigossou, Genevieve& Akoton, Romaric…[et al.]. Evidences of the Low Implication of Mosquitoes in the Transmission of Mycobacterium ulcerans, the Causative Agent of Buruli Ulcer. Canadian Journal of Infectious Diseases and Medical Microbiology. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1141522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141522