Inflammasomes in Mycobacterium tuberculosis-Driven Immunity
Joint Authors
Wawrocki, Sebastian
Druszczyńska, Magdalena
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The development of effective innate and subsequent adaptive host immune responses is highly dependent on the production of proinflammatory cytokines that increase the activity of immune cells.
The key role in this process is played by inflammasomes, multimeric protein complexes serving as a platform for caspase-1, an enzyme responsible for proteolytic cleavage of IL-1β and IL-18 precursors.
Inflammasome activation, which triggers the multifaceted activity of these two proinflammatory cytokines, is a prerequisite for developing an efficient inflammatory response against pathogenic Mycobacterium tuberculosis (M.tb).
This review focuses on the role of NLRP3 and AIM2 inflammasomes in M.tb-driven immunity.
American Psychological Association (APA)
Wawrocki, Sebastian& Druszczyńska, Magdalena. 2017. Inflammasomes in Mycobacterium tuberculosis-Driven Immunity. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1141544
Modern Language Association (MLA)
Wawrocki, Sebastian& Druszczyńska, Magdalena. Inflammasomes in Mycobacterium tuberculosis-Driven Immunity. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1141544
American Medical Association (AMA)
Wawrocki, Sebastian& Druszczyńska, Magdalena. Inflammasomes in Mycobacterium tuberculosis-Driven Immunity. Canadian Journal of Infectious Diseases and Medical Microbiology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1141544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141544