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Oral Yeast Colonization and Fungal Infections in Peritoneal Dialysis Patients: A Pilot Study
Joint Authors
Sampaio-Maia, Benedita
Simões-Silva, Liliana
Pestana, Manuel
Isabel, Soares-Silva
Santos-Araujo, Carla
Silva, Sara
Sousa, Joana
Araujo, Ricardo
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Peritonitis and exit-site infections are important complications in peritoneal dialysis (PD) patients that are occasionally caused by opportunistic fungi inhabiting distant body sites.
In this study, the oral yeast colonization of PD patients and the antifungal susceptibility profile of the isolated yeasts were accessed and correlated with fungal infection episodes in the following 4 years.
Saliva yeast colonization was accessed in 21 PD patients and 27 healthy controls by growth in CHROMagar-Candida® and 18S rRNA/ITS sequencing.
PD patients presented a lower oral yeast prevalence when compared to controls, namely, Candida albicans.
Other species were also isolated, Candida glabrata and Candida carpophila.
The antifungal susceptibility profiles of these isolates revealed resistance to itraconazole, variable susceptibility to caspofungin, and higher MIC values of posaconazole compared to previous reports.
The 4-year longitudinal evaluation of these patients revealed Candida parapsilosis and Candida zeylanoides as PD-related exit-site infectious agents, but no correlation was found with oral yeast colonization.
This pilot study suggests that oral yeast colonization may represent a limited risk for fungal infection development in PD patients.
Oral yeast isolates presented a variable antifungal susceptibility profile, which may suggest resistance to some second-line drugs, highlighting the importance of antifungal susceptibility assessment in the clinical practice.
American Psychological Association (APA)
Simões-Silva, Liliana& Silva, Sara& Santos-Araujo, Carla& Sousa, Joana& Pestana, Manuel& Araujo, Ricardo…[et al.]. 2017. Oral Yeast Colonization and Fungal Infections in Peritoneal Dialysis Patients: A Pilot Study. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1141573
Modern Language Association (MLA)
Simões-Silva, Liliana…[et al.]. Oral Yeast Colonization and Fungal Infections in Peritoneal Dialysis Patients: A Pilot Study. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1141573
American Medical Association (AMA)
Simões-Silva, Liliana& Silva, Sara& Santos-Araujo, Carla& Sousa, Joana& Pestana, Manuel& Araujo, Ricardo…[et al.]. Oral Yeast Colonization and Fungal Infections in Peritoneal Dialysis Patients: A Pilot Study. Canadian Journal of Infectious Diseases and Medical Microbiology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1141573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141573