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Potential Impact of Rapid Blood Culture Testing for Gram-Positive Bacteremia in Japan with the Verigene Gram-Positive Blood Culture Test
Joint Authors
Kikuchi, Ken
Matsuda, Mari
Iguchi, Shigekazu
Mizutani, Tomonori
Hiramatsu, Keiichi
Tega-Ishii, Michiru
Sansaka, Kaori
Negishi, Kenta
Shimada, Kimie
Umemura, Jun
Notake, Shigeyuki
Yanagisawa, Hideji
Takahashi, Hiroshi
Yabusaki, Reiko
Araoka, Hideki
Yoneyama, Akiko
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Early detection of Gram-positive bacteremia and timely appropriate antimicrobial therapy are required for decreasing patient mortality.
The purpose of our study was to evaluate the performance of the Verigene Gram-positive blood culture assay (BC-GP) in two special healthcare settings and determine the potential impact of rapid blood culture testing for Gram-positive bacteremia within the Japanese healthcare delivery system.
Furthermore, the study included simulated blood cultures, which included a library of well-characterized methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) isolates reflecting different geographical regions in Japan.
Methods.
A total 347 BC-GP assays were performed on clinical and simulated blood cultures.
BC-GP results were compared to results obtained by reference methods for genus/species identification and detection of resistance genes using molecular and MALDI-TOF MS methodologies.
Results.
For identification and detection of resistance genes at two clinical sites and simulated blood cultures, overall concordance of BC-GP with reference methods was 327/347 (94%).
The time for identification and antimicrobial resistance detection by BC-GP was significantly shorter compared to routine testing especially at the cardiology hospital, which does not offer clinical microbiology services on weekends and holidays.
Conclusion.
BC-GP generated accurate identification and detection of resistance markers compared with routine laboratory methods for Gram-positive organisms in specialized clinical settings providing more rapid results than current routine testing.
American Psychological Association (APA)
Kikuchi, Ken& Matsuda, Mari& Iguchi, Shigekazu& Mizutani, Tomonori& Hiramatsu, Keiichi& Tega-Ishii, Michiru…[et al.]. 2017. Potential Impact of Rapid Blood Culture Testing for Gram-Positive Bacteremia in Japan with the Verigene Gram-Positive Blood Culture Test. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141574
Modern Language Association (MLA)
Kikuchi, Ken…[et al.]. Potential Impact of Rapid Blood Culture Testing for Gram-Positive Bacteremia in Japan with the Verigene Gram-Positive Blood Culture Test. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1141574
American Medical Association (AMA)
Kikuchi, Ken& Matsuda, Mari& Iguchi, Shigekazu& Mizutani, Tomonori& Hiramatsu, Keiichi& Tega-Ishii, Michiru…[et al.]. Potential Impact of Rapid Blood Culture Testing for Gram-Positive Bacteremia in Japan with the Verigene Gram-Positive Blood Culture Test. Canadian Journal of Infectious Diseases and Medical Microbiology. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141574