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Severe Vitamin B12 Deficiency in Pregnancy Mimicking HELLP Syndrome
Joint Authors
Govindappagari, Shravya
Nguyen, Michelle
Gupta, Megha
Burwick, Richard M.
Hanna, Ramy Magdy
Source
Case Reports in Obstetrics and Gynecology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Severe vitamin B12 deficiency may present with hematologic abnormalities that mimic thrombotic microangiopathy disorders such as hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome.
We report a patient diagnosed with severe vitamin B12 deficiency, following termination of pregnancy for suspected preeclampsia and HELLP syndrome at 21 weeks’ gestation.
When hemolysis and thrombocytopenia persisted after delivery, testing was performed to rule out other etiologies of thrombotic microangiopathy, including atypical hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, and vitamin B12 deficiency.
This work-up revealed undetectable vitamin B12 levels and presence of intrinsic factor antibodies, consistent with pernicious anemia.
Parenteral B12 supplementation was initiated, with subsequent improvement in hematologic parameters.
Our case emphasizes the importance of screening for B12 deficiency in pregnancy, especially in at-risk women with unexplained anemia or thrombocytopenia.
Moreover, providers should consider B12 deficiency and pernicious anemia in the differential diagnosis of pregnancy-associated thrombotic microangiopathy.
American Psychological Association (APA)
Govindappagari, Shravya& Nguyen, Michelle& Gupta, Megha& Hanna, Ramy Magdy& Burwick, Richard M.. 2019. Severe Vitamin B12 Deficiency in Pregnancy Mimicking HELLP Syndrome. Case Reports in Obstetrics and Gynecology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1141649
Modern Language Association (MLA)
Govindappagari, Shravya…[et al.]. Severe Vitamin B12 Deficiency in Pregnancy Mimicking HELLP Syndrome. Case Reports in Obstetrics and Gynecology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1141649
American Medical Association (AMA)
Govindappagari, Shravya& Nguyen, Michelle& Gupta, Megha& Hanna, Ramy Magdy& Burwick, Richard M.. Severe Vitamin B12 Deficiency in Pregnancy Mimicking HELLP Syndrome. Case Reports in Obstetrics and Gynecology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1141649
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141649