MicroPETCT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer
Joint Authors
Wang, Wanqin
Zhao, Jun
Wen, Xiaoxia
Lin, Curtis Chun-Jen
Li, Junjie
Huang, Qian
Yu, Yongqiang
Lin, Shiaw-Yih
Li, Chun
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
AXL receptor tyrosine kinase is overexpressed in a number of solid tumor types including triple-negative breast cancer (TNBC).
AXL is considered an important regulator of epithelial-to-mesenchymal transition (EMT) and a potential therapeutic target for TNBC.
In this work, we used microPET/CT with 64Cu-labeled anti-human AXL antibody (64Cu-anti-hAXL) to noninvasively interrogate the degradation of AXL in vivo in response to 17-allylamino-17-demethoxygeldanamycin (17-AAG), a potent inhibitor of HSP90.
17-AAG treatment caused significant decline in AXL expression in orthotopic TNBC MDA-MB-231 tumors, inhibited EMT, and delayed tumor growth in vivo, resulting in significant reduction in tumor uptake of 64Cu-anti-hAXL as clearly visualized by microPET/CT.
Our data indicate that 64Cu-anti-hAXL can be useful for monitoring anti-AXL therapies and for assessing inhibition of HSP90 molecular chaperone using AXL as a molecular surrogate.
American Psychological Association (APA)
Wang, Wanqin& Zhao, Jun& Wen, Xiaoxia& Lin, Curtis Chun-Jen& Li, Junjie& Huang, Qian…[et al.]. 2017. MicroPETCT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1141681
Modern Language Association (MLA)
Wang, Wanqin…[et al.]. MicroPETCT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1141681
American Medical Association (AMA)
Wang, Wanqin& Zhao, Jun& Wen, Xiaoxia& Lin, Curtis Chun-Jen& Li, Junjie& Huang, Qian…[et al.]. MicroPETCT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1141681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141681