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C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome
Joint Authors
Yamashita, Atsushi
Asada, Yujiro
Sameshima, Hiroshi
Kodama, Yuki
Muraoka, Junsuke
Sato, Yuichiro
Yamaguchi, Tomoko
Taniguchi, Hajime
Kisanuki, Atsushi
Maekawa, Kazunari
Aman, Murasaki
Source
Case Reports in Obstetrics and Gynecology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Neonatal lupus syndrome (NLS) is a rare, passively acquired autoimmune syndrome caused by maternal autoantibodies.
We describe a case of a newborn with NLS and the accompanying placental findings.
A female neonate was born by emergency cesarean delivery due to non-reassuring fetal status at 35 weeks and 3 days.
This neonate had congenital erythematous and scar lesions on the face, back, and upper and lower extremities.
Maternal and fetal anti-SSA and SSB antibodies were elevated and this baby was diagnosed as NLS.
Histologically, the chorionic villi demonstrated capillary shrinkage.
An immunohistochemical study revealed complement deposition (C4d) in the capillaries of the villi and umbilical vessels.
Our findings suggest that maternal autoantibodies affect the inflammatory response of the fetus through the placenta and that C4d deposition may be useful for diagnosing NLS.
American Psychological Association (APA)
Sato, Yuichiro& Yamaguchi, Tomoko& Muraoka, Junsuke& Taniguchi, Hajime& Kisanuki, Atsushi& Maekawa, Kazunari…[et al.]. 2019. C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome. Case Reports in Obstetrics and Gynecology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1141694
Modern Language Association (MLA)
Sato, Yuichiro…[et al.]. C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome. Case Reports in Obstetrics and Gynecology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1141694
American Medical Association (AMA)
Sato, Yuichiro& Yamaguchi, Tomoko& Muraoka, Junsuke& Taniguchi, Hajime& Kisanuki, Atsushi& Maekawa, Kazunari…[et al.]. C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome. Case Reports in Obstetrics and Gynecology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1141694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141694