CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches
Joint Authors
Spiegelberg, Diana
Nilvebrant, Johan
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Head and neck squamous cell carcinoma (HNSCC) is a common and severe cancer with low survival rate in advanced stages.
Noninvasive imaging of prognostic and therapeutic biomarkers could provide valuable information for planning and monitoring of the different therapy options.
Thus, there is a major interest in development of new tracers towards cancer-specific molecular targets to improve diagnostic imaging and treatment.
CD44v6, an oncogenic variant of the cell surface molecule CD44, is a promising molecular target since it exhibits a unique expression pattern in HNSCC and is associated with drug- and radio-resistance.
In this review we summarize results from preclinical and clinical investigations of radiolabeled anti-CD44v6 antibody-based tracers: full-length antibodies, Fab, F(ab′)2 fragments, and scFvs with particular focus on the engineering of various antibody formats and choice of radiolabel for the use as molecular imaging agents in HNSCC.
We conclude that the current evidence points to CD44v6 imaging being a promising approach for providing more specific and sensitive diagnostic tools, leading to customized treatment decisions and functional diagnosis.
Improved imaging tools hold promise to enable more effective treatment for head and neck cancer patients.
American Psychological Association (APA)
Spiegelberg, Diana& Nilvebrant, Johan. 2017. CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1141700
Modern Language Association (MLA)
Spiegelberg, Diana& Nilvebrant, Johan. CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1141700
American Medical Association (AMA)
Spiegelberg, Diana& Nilvebrant, Johan. CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1141700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141700