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Gd3+-Asparagine-Anionic Linear Globular Dendrimer Second-Generation G2 Complexes: Novel Nanobiohybrid Theranostics
Joint Authors
Shafiee Ardestani, Mehdi
Saffari, Mostafa
Hashempour Alamdari, Nasim
Alaei-Beirami, Mahmood
Sadat Shandiz, Seyed Ataollah
Hejazinia, Hadi
Rasouli, Rahimeh
Sadat Ebrahimi, Seyed Esmaeil
Assadi, Artin
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-26
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Designing a unique theranostic biocompatible, biodegradable, and cost-effective agent which is easy to be synthesized as a biohybrid material was the aim of this study.
In this matter, asparagine attached to anionic linear globular dendrimer G2 (as a biocompatible, biodegradable, and cost-effective agent which is negatively charged nanosized and water soluble polymer that outweighs other traditionally used dendrimers) and finally contrast agent (Gd3+) was loaded (which made complexes) in synthesized asparagine-dendrimer.
Observations revealed that, in addition to successful colon cancer and brain targeting, Gd3+-dendrimer-asparagine, the proposed theranostic agent, could increase T1 MR relaxation times, decrease T2 MR relaxation times significantly, and improve contrast of image as well as illustrating good cellular uptake based on florescent microscopy/flow cytometry and ICP-mass data.
In addition to that, it increased tumor growth inhibition percentage (TGI%) significantly compared to FDA approved contrast agent, Magnevist.
Totally, Gd3+-anionic linear globular dendrimer G2-asparagine could be introduced to the cancer imaging/therapy (theranostics) protocols after in vivo MR and fluorescent analysis and passing clinical trials.
Hence, this nanotheranostic agent would be a promising candidate for brain drug delivery and imaging in the future.
American Psychological Association (APA)
Hashempour Alamdari, Nasim& Alaei-Beirami, Mahmood& Sadat Shandiz, Seyed Ataollah& Hejazinia, Hadi& Rasouli, Rahimeh& Saffari, Mostafa…[et al.]. 2017. Gd3+-Asparagine-Anionic Linear Globular Dendrimer Second-Generation G2 Complexes: Novel Nanobiohybrid Theranostics. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1141725
Modern Language Association (MLA)
Hashempour Alamdari, Nasim…[et al.]. Gd3+-Asparagine-Anionic Linear Globular Dendrimer Second-Generation G2 Complexes: Novel Nanobiohybrid Theranostics. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1141725
American Medical Association (AMA)
Hashempour Alamdari, Nasim& Alaei-Beirami, Mahmood& Sadat Shandiz, Seyed Ataollah& Hejazinia, Hadi& Rasouli, Rahimeh& Saffari, Mostafa…[et al.]. Gd3+-Asparagine-Anionic Linear Globular Dendrimer Second-Generation G2 Complexes: Novel Nanobiohybrid Theranostics. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1141725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141725