Preliminary 19F-MRS Study of Tumor Cell Proliferation with 3′-deoxy-3′-fluorothymidine and Its Metabolite (FLT-MP)
Joint Authors
Lim, Sang Moo
Jung, Ki-Hye
Park, Ji-Ae
Kim, Jung Young
Kim, Mi Hyun
Lee, Kyo Chul
Kim, Kyeong Min
Lee, Yong Jin
Kang, Kyung Jun
Ko, In Ok
Noh, Insup
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The thymidine analogue 3′-deoxy-3′-[18F]fluorothymidine, or [18F]fluorothymidine ([18F]FLT), is used to measure tumor cell proliferation with positron emission tomography (PET) imaging technology in nuclear medicine.
FLT is phosphorylated by thymidine kinase 1 (TK1) and then trapped inside cells; it is not incorporated into DNA.
Imaging with 18F-radiolabeled FLT is a noninvasive technique to visualize cellular proliferation in tumors.
However, it is difficult to distinguish between [18F]FLT and its metabolites by PET imaging, and quantification has not been attempted using current imaging methods.
In this study, we successfully acquired in vivo F19 spectra of natural or nonradioactive 3′-deoxy-3′-fluorothymidine ([19F]FLT) and its monophosphate metabolite (FLT-MP) in a tumor xenograft mouse model using 9.4T magnetic resonance imaging (MRI).
This preliminary result demonstrates that 19F magnetic resonance spectroscopy (MRS) with FLT is suitable for the in vivo assessment of tumor aggressiveness and for early prediction of treatment response.
American Psychological Association (APA)
Ko, In Ok& Jung, Ki-Hye& Kim, Mi Hyun& Kang, Kyung Jun& Lee, Kyo Chul& Kim, Kyeong Min…[et al.]. 2017. Preliminary 19F-MRS Study of Tumor Cell Proliferation with 3′-deoxy-3′-fluorothymidine and Its Metabolite (FLT-MP). Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1141732
Modern Language Association (MLA)
Ko, In Ok…[et al.]. Preliminary 19F-MRS Study of Tumor Cell Proliferation with 3′-deoxy-3′-fluorothymidine and Its Metabolite (FLT-MP). Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1141732
American Medical Association (AMA)
Ko, In Ok& Jung, Ki-Hye& Kim, Mi Hyun& Kang, Kyung Jun& Lee, Kyo Chul& Kim, Kyeong Min…[et al.]. Preliminary 19F-MRS Study of Tumor Cell Proliferation with 3′-deoxy-3′-fluorothymidine and Its Metabolite (FLT-MP). Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1141732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141732