Meta-Analysis of the Correlation between Apparent Diffusion Coefficient and Standardized Uptake Value in Malignant Disease
Joint Authors
Yan, Jianhua
Deng, Shengming
Zhang, Bin
Zhang, Wei
Wu, Zhifang
Wu, Yiwei
Li, Jihui
Dai, Na
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The objective of this meta-analysis is to explore the correlation between the apparent diffusion coefficient (ADC) on diffusion-weighted MR and the standard uptake value (SUV) of 18F-FDG on PET/CT in patients with cancer.
Databases such as PubMed (MEDLINE included), EMBASE, and Cochrane Database of Systematic Review were searched for relevant original articles that explored the correlation between SUV and ADC in English.
After applying Fisher’s r-to-z transformation, correlation coefficient (r) values were extracted from each study and 95% confidence intervals (CIs) were calculated.
Sensitivity and subgroup analyses based on tumor type were performed to investigate the potential heterogeneity.
Forty-nine studies were eligible for the meta-analysis, comprising 1927 patients.
Pooled r for all studies was −0.35 (95% CI: −0.42–0.28) and exhibited a notable heterogeneity (I2 = 78.4%; P < 0.01).
In terms of the cancer type subgroup analysis, combined correlation coefficients of ADC/SUV range from −0.12 (lymphoma, n = 5) to −0.59 (pancreatic cancer, n = 2).
We concluded that there is an average negative correlation between ADC and SUV in patients with cancer.
Higher correlations were found in the brain tumor, cervix carcinoma, and pancreas cancer.
However, a larger, prospective study is warranted to validate these findings in different cancer types.
American Psychological Association (APA)
Deng, Shengming& Wu, Zhifang& Wu, Yiwei& Zhang, Wei& Li, Jihui& Dai, Na…[et al.]. 2017. Meta-Analysis of the Correlation between Apparent Diffusion Coefficient and Standardized Uptake Value in Malignant Disease. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1141755
Modern Language Association (MLA)
Deng, Shengming…[et al.]. Meta-Analysis of the Correlation between Apparent Diffusion Coefficient and Standardized Uptake Value in Malignant Disease. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1141755
American Medical Association (AMA)
Deng, Shengming& Wu, Zhifang& Wu, Yiwei& Zhang, Wei& Li, Jihui& Dai, Na…[et al.]. Meta-Analysis of the Correlation between Apparent Diffusion Coefficient and Standardized Uptake Value in Malignant Disease. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1141755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141755