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Fluorine-19 Magnetic Resonance Imaging and Positron Emission Tomography of Tumor-Associated Macrophages and Tumor Metabolism
Joint Authors
Shin, Soo Hyun
Park, Sang Hyun
Kang, Se Hun
Kim, Seung Won
Kim, Minsun
Kim, Daehong
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The presence of tumor-associated macrophages (TAMs) is significantly associated with poor prognosis of tumors.
Currently, magnetic resonance imaging- (MRI-) based TAM imaging methods that use nanoparticles such as superparamagnetic iron oxide and perfluorocarbon nanoemulsions are available for quantitative monitoring of TAM burden in tumors.
However, whether MRI-based measurements of TAMs can be used as prognostic markers has not been evaluated yet.
In this study, we used positron emission tomography (PET) with 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) as a radioactive tracer and fluorine-19- (19F-) MRI for imaging mouse breast cancer models to determine any association between TAM infiltration and tumor metabolism.
Perfluorocarbon nanoemulsions were intravenously administered to track and quantify TAM infiltration using a 7T MR scanner.
To analyze glucose uptake in tumors, 18F-FDG-PET images were acquired immediately after 19F-MRI.
Coregistered 18F-FDG-PET and 19F-MR images enabled comparison of spatial patterns of glucose uptake and TAM distribution in tumors.
19F-MR signal intensities from tumors exhibited a strong inverse correlation with 18F-FDG uptake while having a significant positive correlation with tumor growth from days 2 to 7.
These results show that combination of 19F-MRI and 18F-FDG-PET can improve our understanding of the relationship between TAM and tumor microenvironment.
American Psychological Association (APA)
Shin, Soo Hyun& Park, Sang Hyun& Kang, Se Hun& Kim, Seung Won& Kim, Minsun& Kim, Daehong. 2017. Fluorine-19 Magnetic Resonance Imaging and Positron Emission Tomography of Tumor-Associated Macrophages and Tumor Metabolism. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141758
Modern Language Association (MLA)
Shin, Soo Hyun…[et al.]. Fluorine-19 Magnetic Resonance Imaging and Positron Emission Tomography of Tumor-Associated Macrophages and Tumor Metabolism. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1141758
American Medical Association (AMA)
Shin, Soo Hyun& Park, Sang Hyun& Kang, Se Hun& Kim, Seung Won& Kim, Minsun& Kim, Daehong. Fluorine-19 Magnetic Resonance Imaging and Positron Emission Tomography of Tumor-Associated Macrophages and Tumor Metabolism. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141758
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141758