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Associations between 18F-FDG-PET, DWI, and DCE Parameters in Patients with Head and Neck Squamous Cell Carcinoma Depend on Tumor Grading
Joint Authors
Meyer, Hans Jonas
Leifels, Leonard
Surov, Alexey
Purz, Sandra
Sabri, Osama
Stumpp, Patrick
Schob, Stefan
Kahn, Thomas
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Our purpose was to analyze associations between positron emission tomography (PET), diffusion weighted imaging (DWI), and dynamic contrast-enhanced (DCE) imaging in patients with head and neck squamous cell carcinoma (HNSCC).
The study involved 34 patients (9 women, 25 men, mean age: 56.7±10.2 years).
In all patients a simultaneous 18F-FDG-PET/MR was performed.
DWI was obtained by using of an axial EPI sequence.
Minimal ADC values (ADCmin), mean ADC values (ADCmean), and maximal ADC values (ADCmax) were estimated.
DCE MRI was performed by using dynamic T1w DCE sequence.
The following parameters were estimated: Ktrans, Ve, and Kep.
Spearman’s correlation coefficient was used to analyze associations between investigated parameters.
In overall sample, ADCmean correlated significantly with Ve and Ktrans, ADCmin correlated with Ve, and ADCmax correlated with Ktrans and Ve.
SUVmean tended to correlate slightly with Ktrans.
In G1/2 tumors, only Ktrans correlated well with ADCmax and SUVmean.
In G3 tumors, Ktrans correlated well with Kep and Ve.
Ve showed significant correlations with ADCmean and ADCmax.
Ktrans correlated with ADCmax.
Kep was higher in cancers with N2/3 stages.
Tumor metabolism, water diffusion, and tumor perfusion have complex relationships in HNSCC.
Furthermore, these associations depend on tumor grading.
Kep may predict lymphonodal metastasizing.
American Psychological Association (APA)
Leifels, Leonard& Purz, Sandra& Stumpp, Patrick& Schob, Stefan& Meyer, Hans Jonas& Kahn, Thomas…[et al.]. 2017. Associations between 18F-FDG-PET, DWI, and DCE Parameters in Patients with Head and Neck Squamous Cell Carcinoma Depend on Tumor Grading. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141774
Modern Language Association (MLA)
Leifels, Leonard…[et al.]. Associations between 18F-FDG-PET, DWI, and DCE Parameters in Patients with Head and Neck Squamous Cell Carcinoma Depend on Tumor Grading. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1141774
American Medical Association (AMA)
Leifels, Leonard& Purz, Sandra& Stumpp, Patrick& Schob, Stefan& Meyer, Hans Jonas& Kahn, Thomas…[et al.]. Associations between 18F-FDG-PET, DWI, and DCE Parameters in Patients with Head and Neck Squamous Cell Carcinoma Depend on Tumor Grading. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141774