Uptake of 18F-FET and 18F-FCH in Human Glioblastoma T98G Cell Line after Irradiation with Photons or Carbon Ions
Joint Authors
Hodolic, M.
Persico, Marco Giovanni
Aprile, Carlo
Lodola, Lorenzo
Buroni, Federica Eleonora
Corbella, Franco
Facoetti, Angelica
Nano, Rosanna
Pasi, Francesca
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The differential diagnosis between recurrence of gliomas or brain metastases and this phenomenon is important in order to choose the best therapy and predict the prognosis but is still a big problem for physicians.
The new emerging MRI, CT, and PET diagnostic modalities still lack sufficient accuracy.
Radiolabeled choline and amino acids have been reported to show great tumor specificity.
We studied the uptake kinetics of [18F]fluoromethyl-choline (FCH) and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) by the T98G human glioblastoma cells from 20 to 120 min after irradiation either with photons at 2-10-20 Gy or with carbon ions at 2 Gy (at the National Centre for Oncological Hadrontherapy (CNAO), Pavia, Italy).
We also evaluated the cell death and morphology changes induced by radiation treatment.
Both FET and FCH are able to trace tumor behavior in terms of higher uptake for increased doses of radiation treatment, due to the upregulation of cells attempts to repair nonlethal damage.
Our data suggest that both FCH and FET could be useful to analyze the metabolic pathways of glioblastoma cells before and after radiotherapy.
Physicians will have to consider the different kinetics pathways of uptake concerning the two radiopharmaceuticals.
American Psychological Association (APA)
Pasi, Francesca& Persico, Marco Giovanni& Buroni, Federica Eleonora& Aprile, Carlo& Hodolic, M.& Corbella, Franco…[et al.]. 2017. Uptake of 18F-FET and 18F-FCH in Human Glioblastoma T98G Cell Line after Irradiation with Photons or Carbon Ions. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141813
Modern Language Association (MLA)
Pasi, Francesca…[et al.]. Uptake of 18F-FET and 18F-FCH in Human Glioblastoma T98G Cell Line after Irradiation with Photons or Carbon Ions. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1141813
American Medical Association (AMA)
Pasi, Francesca& Persico, Marco Giovanni& Buroni, Federica Eleonora& Aprile, Carlo& Hodolic, M.& Corbella, Franco…[et al.]. Uptake of 18F-FET and 18F-FCH in Human Glioblastoma T98G Cell Line after Irradiation with Photons or Carbon Ions. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1141813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141813