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In Vivo PET Imaging of Adenosine 2A Receptors in Neuroinflammatory and Neurodegenerative Disease
Joint Authors
Vuorimaa, Anna
Rissanen, Eero
Airas, Laura
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-20
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Adenosine receptors are G-protein coupled P1 purinergic receptors that are broadly expressed in the peripheral immune system, vasculature, and the central nervous system (CNS).
Within the immune system, adenosine 2A (A2A) receptor-mediated signaling exerts a suppressive effect on ongoing inflammation.
In healthy CNS, A2A receptors are expressed mainly within the neurons of the basal ganglia.
Alterations in A2A receptor function and expression have been noted in movement disorders, and in Parkinson’s disease pharmacological A2A receptor antagonism leads to diminished motor symptoms.
Although A2A receptors are expressed only at a low level in the healthy CNS outside striatum, pathological challenge or inflammation has been shown to lead to upregulation of A2A receptors in extrastriatal CNS tissue, and this has been successfully quantitated using in vivo positron emission tomography (PET) imaging and A2A receptor-binding radioligands.
Several radioligands for PET imaging of A2A receptors have been developed in recent years, and A2A receptor-targeting PET imaging may thus provide a potential additional tool to evaluate various aspects of neuroinflammation in vivo.
This review article provides a brief overview of A2A receptors in healthy brain and in a selection of most important neurological diseases and describes the recent advances in A2A receptor-targeting PET imaging studies.
American Psychological Association (APA)
Vuorimaa, Anna& Rissanen, Eero& Airas, Laura. 2017. In Vivo PET Imaging of Adenosine 2A Receptors in Neuroinflammatory and Neurodegenerative Disease. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1141826
Modern Language Association (MLA)
Vuorimaa, Anna…[et al.]. In Vivo PET Imaging of Adenosine 2A Receptors in Neuroinflammatory and Neurodegenerative Disease. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1141826
American Medical Association (AMA)
Vuorimaa, Anna& Rissanen, Eero& Airas, Laura. In Vivo PET Imaging of Adenosine 2A Receptors in Neuroinflammatory and Neurodegenerative Disease. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1141826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141826