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Erbium-Based Perfusion Contrast Agent for Small-Animal Microvessel Imaging
Joint Authors
Tse, Justin J.
Dunmore-Buyze, P. Joy
Drangova, Maria
Holdsworth, David W.
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Micro-computed tomography (micro-CT) facilitates the visualization and quantification of contrast-enhanced microvessels within intact tissue specimens, but conventional preclinical vascular contrast agents may be inadequate near dense tissue (such as bone).
Typical lead-based contrast agents do not exhibit optimal X-ray absorption properties when used with X-ray tube potentials below 90 kilo-electron volts (keV).
We have developed a high-atomic number lanthanide (erbium) contrast agent, with a K-edge at 57.5 keV.
This approach optimizes X-ray absorption in the output spectral band of conventional microfocal spot X-ray tubes.
Erbium oxide nanoparticles (nominal diameter < 50 nm) suspended in a two-part silicone elastomer produce a perfusable fluid with viscosity of 19.2 mPa-s.
Ultrasonic cavitation was used to reduce aggregate sizes to <70 nm.
Postmortem intact mice were perfused to investigate the efficacy of contrast agent.
The observed vessel contrast was >4000 Hounsfield units, and perfusion of vessels < 10 μm in diameter was demonstrated in kidney glomeruli.
The described new contrast agent facilitated the visualization and quantification of vessel density and microarchitecture, even adjacent to dense bone.
Erbium’s K-edge makes this contrast agent ideally suited for both single- and dual-energy micro-CT, expanding potential preclinical research applications in models of musculoskeletal, oncological, cardiovascular, and neurovascular diseases.
American Psychological Association (APA)
Tse, Justin J.& Dunmore-Buyze, P. Joy& Drangova, Maria& Holdsworth, David W.. 2017. Erbium-Based Perfusion Contrast Agent for Small-Animal Microvessel Imaging. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141838
Modern Language Association (MLA)
Tse, Justin J.…[et al.]. Erbium-Based Perfusion Contrast Agent for Small-Animal Microvessel Imaging. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1141838
American Medical Association (AMA)
Tse, Justin J.& Dunmore-Buyze, P. Joy& Drangova, Maria& Holdsworth, David W.. Erbium-Based Perfusion Contrast Agent for Small-Animal Microvessel Imaging. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141838