![](/images/graphics-bg.png)
Response of Leptomeningeal Metastases in EGFR-Mutated Non-Small-Cell Lung Cancer to Afatinib in the Absence of Radiotherapy
Joint Authors
Cuello, Javier
Llinás-Quintero, Néstor
González-Hoyos, David
Yepes, Andrés
Herrera, Diego A.
Peláez-Arroyave, Sebastián
Caicedo-Zamudio, Carlos
Blanco-Daza, Erick
Source
Case Reports in Oncological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Palliative radiotherapy is currently the medical standard of care for non-small-cell lung cancer (NSCLC) patients with symptomatic CNS and leptomeningeal disease.
We report the case of a 62-year-old male patient with EGFR mutation (del19+) NSLC with symptomatic lymph node, bone, CNS, and leptomeningeal metastases.
Taking into account on one hand the response to tyrosine kinase inhibitors (TKIs) and on the other hand the short- to medium-term side effects of radiotherapy and the lack of timely availability in our healthcare system, the patient was treated with afatinib (40 mg daily) and exhibited a rapid response with improvement of neurological symptoms.
The patient presented partial response of extracranial, CNS, and leptomeningeal lesions at 3, 6, and 12 months of treatment, currently completing 16 months of progression-free survival despite presenting mild dermatological and gastrointestinal toxicities.
Afatinib is an effective and safe option in patients with NSLC EGFR mutation del19+ with CNS and leptomeningeal compromise avoiding or delaying radiotherapy and its side effects, especially in countries where there is a lack of access to this kind of therapy.
American Psychological Association (APA)
Llinás-Quintero, Néstor& González-Hoyos, David& Yepes, Andrés& Herrera, Diego A.& Peláez-Arroyave, Sebastián& Caicedo-Zamudio, Carlos…[et al.]. 2019. Response of Leptomeningeal Metastases in EGFR-Mutated Non-Small-Cell Lung Cancer to Afatinib in the Absence of Radiotherapy. Case Reports in Oncological Medicine،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1141859
Modern Language Association (MLA)
Llinás-Quintero, Néstor…[et al.]. Response of Leptomeningeal Metastases in EGFR-Mutated Non-Small-Cell Lung Cancer to Afatinib in the Absence of Radiotherapy. Case Reports in Oncological Medicine No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1141859
American Medical Association (AMA)
Llinás-Quintero, Néstor& González-Hoyos, David& Yepes, Andrés& Herrera, Diego A.& Peláez-Arroyave, Sebastián& Caicedo-Zamudio, Carlos…[et al.]. Response of Leptomeningeal Metastases in EGFR-Mutated Non-Small-Cell Lung Cancer to Afatinib in the Absence of Radiotherapy. Case Reports in Oncological Medicine. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1141859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141859