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Key Parameters on the Microwave Assisted Synthesis of Magnetic Nanoparticles for MRI Contrast Agents
Joint Authors
Morales, Maria P.
Brollo, Maria Eugênia Fortes
Veintemillas-Verdaguer, Sabino
Salván, Cesar Menor
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Uniform iron oxide magnetic nanoparticles have been synthesized using a microwave assisted synthesis method in organic media and their colloidal, magnetic, and relaxometric properties have been analyzed after its transference to water and compared with those nanoparticles prepared by thermal decomposition in organic media.
The novelty of this synthesis relies on the use of a solid iron oleate as precursor, which assures the reproducibility and scalability of the synthesis, and the microwave heating that resulted in being faster and more efficient than traditional heating methods, and therefore it has a great potential for nanoparticle industrial production.
The effect of different experimental conditions such as the solvent, precursor, and surfactant concentration and reaction time as well as the transference to water is analyzed and optimized to obtain magnetic iron oxide nanoparticles with sizes between 8 and 15 nm and finally colloids suitable for their use as contrast agents on Magnetic Resonance Imaging (MRI).
The r2 relaxivity values normalized to the square of the saturation magnetization were shown to be constant and independent of the particle size, which means that the saturation magnetization is the main parameter controlling the efficiency of these magnetic nanoparticles as MRI T2-contrast agents.
American Psychological Association (APA)
Brollo, Maria Eugênia Fortes& Veintemillas-Verdaguer, Sabino& Salván, Cesar Menor& Morales, Maria P.. 2017. Key Parameters on the Microwave Assisted Synthesis of Magnetic Nanoparticles for MRI Contrast Agents. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1141874
Modern Language Association (MLA)
Brollo, Maria Eugênia Fortes…[et al.]. Key Parameters on the Microwave Assisted Synthesis of Magnetic Nanoparticles for MRI Contrast Agents. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1141874
American Medical Association (AMA)
Brollo, Maria Eugênia Fortes& Veintemillas-Verdaguer, Sabino& Salván, Cesar Menor& Morales, Maria P.. Key Parameters on the Microwave Assisted Synthesis of Magnetic Nanoparticles for MRI Contrast Agents. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1141874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141874