Kinetic Modelling of Infection Tracers [18F]FDG, [68Ga]Ga-Citrate, [11C]Methionine, and [11C]Donepezil in a Porcine Osteomyelitis Model
Joint Authors
Alstrup, Aage K. O.
Borghammer, Per
Jensen, Svend B.
Afzelius, Pia
Nielsen, Ole Lerberg
Jødal, Lars
Hansen, Søren B.
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-09
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Introduction.
Positron emission tomography (PET) is increasingly applied for infection imaging using [18F]FDG as tracer, but uptake is unspecific.
The present study compares the kinetics of [18F]FDG and three other PET tracers with relevance for infection imaging.
Methods.
A juvenile porcine osteomyelitis model was used.
Eleven pigs underwent PET/CT with 60-minute dynamic PET imaging of [18F]FDG, [68Ga]Ga-citrate, [11C]methionine, and/or [11C]donepezil, along with blood sampling.
For infectious lesions, kinetic modelling with one- and two-tissue-compartment models was conducted for each tracer.
Results.
Irreversible uptake was found for [18F]FDG and [68Ga]Ga-citrate; reversible uptake was found for [11C]methionine (two-tissue model) and [11C]donepezil (one-tissue model).
The uptake rate for [68Ga]Ga-citrate was slow and diffusion-limited.
For the other tracers, the uptake rate was primarily determined by perfusion (flow-limited uptake).
Net uptake rate for [18F]FDG and distribution volume for [11C]methionine were significantly higher for infectious lesions than for correspondingly noninfected tissue.
For [11C]donepezil in pigs, labelled metabolite products appeared to be important for the analysis.
Conclusions.
The kinetics of the four studied tracers in infection was characterized.
For clinical applications, [18F]FDG remains the first-choice PET tracer.
[11C]methionine may have a potential for detecting soft tissue infections.
[68Ga]Ga-citrate and [11C]donepezil were not found useful for imaging of osteomyelitis.
American Psychological Association (APA)
Jødal, Lars& Jensen, Svend B.& Nielsen, Ole Lerberg& Afzelius, Pia& Borghammer, Per& Alstrup, Aage K. O.…[et al.]. 2017. Kinetic Modelling of Infection Tracers [18F]FDG, [68Ga]Ga-Citrate, [11C]Methionine, and [11C]Donepezil in a Porcine Osteomyelitis Model. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1141879
Modern Language Association (MLA)
Jødal, Lars…[et al.]. Kinetic Modelling of Infection Tracers [18F]FDG, [68Ga]Ga-Citrate, [11C]Methionine, and [11C]Donepezil in a Porcine Osteomyelitis Model. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1141879
American Medical Association (AMA)
Jødal, Lars& Jensen, Svend B.& Nielsen, Ole Lerberg& Afzelius, Pia& Borghammer, Per& Alstrup, Aage K. O.…[et al.]. Kinetic Modelling of Infection Tracers [18F]FDG, [68Ga]Ga-Citrate, [11C]Methionine, and [11C]Donepezil in a Porcine Osteomyelitis Model. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1141879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141879