Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A Resting-State fMRI Study
Joint Authors
Kelekis, Nikolaos
Papathanasiou, Matilda
Bromis, Konstantinos
Gkiatis, Kostakis
Karavasilis, Eustratios
Kouloulias, Vassilis
Efstathopoulos, Efstathios P.
Matsopoulos, George
Karanasiou, Irene
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Previous studies in small-cell lung cancer (SCLC) patients have mainly focused on exploring neurocognitive deficits associated with prophylactic cranial irradiation (PCI).
Little is known about functional brain alterations that might occur due to chemotherapy treatment in this population before PCI is administered.
For this reason, we used resting-state functional Magnetic Resonance Imaging (fMRI) to examine potential functional connectivity disruptions in brain networks, including the Default Mode Network (DMN), the Sensorimotor Network, and the Task-Positive Network (TPN).
Nineteen SCLC patients after platinum-based chemotherapy treatment and thirteen controls were recruited in the current study.
ROI-to-ROI and Seed-to-Voxel analyses were carried out and revealed functional connectivity deficits in patients within all the networks investigated demonstrating the possible negative effect of chemotherapy in cognitive functions in SCLC populations.
American Psychological Association (APA)
Bromis, Konstantinos& Gkiatis, Kostakis& Karanasiou, Irene& Matsopoulos, George& Karavasilis, Eustratios& Papathanasiou, Matilda…[et al.]. 2017. Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A Resting-State fMRI Study. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1141939
Modern Language Association (MLA)
Bromis, Konstantinos…[et al.]. Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A Resting-State fMRI Study. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1141939
American Medical Association (AMA)
Bromis, Konstantinos& Gkiatis, Kostakis& Karanasiou, Irene& Matsopoulos, George& Karavasilis, Eustratios& Papathanasiou, Matilda…[et al.]. Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A Resting-State fMRI Study. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1141939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141939