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A Case of Long-Term Survival after Checkpoint Inhibitor Pneumonitis in a Patient with Squamous Cell Lung Cancer
Joint Authors
Shingyoji, Masato
Ashinuma, Hironori
Mizuno, Satoko
Yoshida, Yasushi
Source
Case Reports in Oncological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The management of grade 1 checkpoint inhibitor pneumonitis (CIP) is to withhold immune checkpoint inhibitors; however, the natural history of this condition is unknown.
We herein report the case of a woman with squamous cell lung cancer who was a long-term survivor after CIP.
After 4 rounds of treatment with nivolumab, a chest CT revealed a reticular pattern and ground-glass attenuation with shrinkage of the primary nodule.
Nivolumab treatment was withheld without the administration of steroids.
Although she remained asymptomatic, subsequent images revealed an increasing interstitial shadow until 2 months after the stop of nivolumab treatment.
Thereafter, the interstitial shadow began to improve spontaneously without steroid treatment.
Moreover, although the patient has not received additional therapy, disease control of lung cancer has been obtained within a follow-up period of more than 3 years.
Although the exacerbation of CIP may appear on images for several months, asymptomatic cases can be followed without the administration of steroids.
If the tumor had already responded prior to the onset of CIP, a favorable long-term prognosis can be expected.
American Psychological Association (APA)
Ashinuma, Hironori& Mizuno, Satoko& Yoshida, Yasushi& Shingyoji, Masato. 2019. A Case of Long-Term Survival after Checkpoint Inhibitor Pneumonitis in a Patient with Squamous Cell Lung Cancer. Case Reports in Oncological Medicine،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1141981
Modern Language Association (MLA)
Ashinuma, Hironori…[et al.]. A Case of Long-Term Survival after Checkpoint Inhibitor Pneumonitis in a Patient with Squamous Cell Lung Cancer. Case Reports in Oncological Medicine No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1141981
American Medical Association (AMA)
Ashinuma, Hironori& Mizuno, Satoko& Yoshida, Yasushi& Shingyoji, Masato. A Case of Long-Term Survival after Checkpoint Inhibitor Pneumonitis in a Patient with Squamous Cell Lung Cancer. Case Reports in Oncological Medicine. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1141981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141981