A Case of Essential Thrombocythemia and IgA Nephropathy with Literature Review of the Concurrence
Joint Authors
Rahimian, Shoja
Johnson, Timothy
Herb, Ronald
Source
Case Reports in Oncological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Myeloproliferative neoplasms such as essential thrombocythemia (ET) have been associated with glomerular disease on rare instances.
A case of ET associated with immunoglobulin A nephropathy (IgAN) is described in a 57-year-old man with a history of hypertension.
Progressively worsening renal function was noted in the patient along with unexplained mild thrombocytosis.
Pathological review of renal biopsy identified IgAN concurrently with newly diagnosed JAK2-mutated ET.
The patient was started on aspirin therapy and closely monitored for his renal function.
A literature review of the association of ET and renal disease revealed nine cases of ET associated with IgAN, focal segmental glomerulosclerosis, and fibrillary glomerulonephritis.
Comparison of the pathological features of the renal biopsies within the cases noted mesangial proliferation as a common finding, which has been described to be potentiated by platelet-derived growth factor (PDGF).
This commonality may represent a link between ET and glomerular disease which deserves further attention in future cases.
Improved management of such cases depends on the recognition of the combined occurrence of ET and glomerular diseases and uncovering the shared pathogenesis between platelets and glomeruli.
American Psychological Association (APA)
Rahimian, Shoja& Johnson, Timothy& Herb, Ronald. 2019. A Case of Essential Thrombocythemia and IgA Nephropathy with Literature Review of the Concurrence. Case Reports in Oncological Medicine،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1142001
Modern Language Association (MLA)
Rahimian, Shoja…[et al.]. A Case of Essential Thrombocythemia and IgA Nephropathy with Literature Review of the Concurrence. Case Reports in Oncological Medicine No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1142001
American Medical Association (AMA)
Rahimian, Shoja& Johnson, Timothy& Herb, Ronald. A Case of Essential Thrombocythemia and IgA Nephropathy with Literature Review of the Concurrence. Case Reports in Oncological Medicine. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1142001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142001