Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4+ T Cells, and Antitumor Cytokine Interactions
Joint Authors
Wei, Hsiu-Chuan
Yu, Jui-Ling
Hsu, Chia-Yu
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Immunotherapy is one of the most recent approaches for controlling and curing malignant tumors.
In this paper, we consider a mathematical model of periodically pulsed immunotherapy using CD4+ T cells and an antitumor cytokine.
Mathematical analyses are performed to determine the threshold of a successful treatment.
The interindividual variability is explored by one-, two-, and three-parameter bifurcation diagrams for a nontreatment case.
Numerical simulation conducted in this paper shows that (i) the tumor can be regulated by administering CD4+ T cells alone in a patient with a strong immune system or who has been diagnosed at an early stage, (ii) immunotherapy with a large amount of an antitumor cytokine can boost the immune system to remit or even to suppress tumor cells completely, and (iii) through polytherapy the tumor can be kept at a smaller size with reduced dosages.
American Psychological Association (APA)
Wei, Hsiu-Chuan& Yu, Jui-Ling& Hsu, Chia-Yu. 2017. Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4+ T Cells, and Antitumor Cytokine Interactions. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1142035
Modern Language Association (MLA)
Wei, Hsiu-Chuan…[et al.]. Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4+ T Cells, and Antitumor Cytokine Interactions. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1142035
American Medical Association (AMA)
Wei, Hsiu-Chuan& Yu, Jui-Ling& Hsu, Chia-Yu. Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4+ T Cells, and Antitumor Cytokine Interactions. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1142035
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142035