Emerging Risk Profile of Lung Cancer Therapy: Diffuse Alveolar Hemorrhage from Osimertinib

Joint Authors

Forte, Michael J.
Sangani, Rahul G.

Source

Case Reports in Oncological Medicine

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-07-30

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Medicine

Abstract EN

Osimertinib is an oral epithelial growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used primarily in the treatment of metastatic non-small cell lung cancer.

It is usually well tolerated with less than 5% of patients developing significant pulmonary toxicity from the medication, typically within the first few months after initiation.

Previously reported pulmonary adverse reactions include pneumonitis (nonspecific interstitial pneumonia or other forms of acute interstitial process), fleeting asymptomatic infiltrates on imaging, and eosinophilic pneumonia.

We present an interesting case of a 65-year-old female with recurrent metastatic adenocarcinoma of the lung, treated with Osimertinib for 4 months, who developed a previously unreported toxicity of diffuse alveolar hemorrhage (DAH) requiring mechanical ventilatory support.

American Psychological Association (APA)

Forte, Michael J.& Sangani, Rahul G.. 2019. Emerging Risk Profile of Lung Cancer Therapy: Diffuse Alveolar Hemorrhage from Osimertinib. Case Reports in Oncological Medicine،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1142038

Modern Language Association (MLA)

Forte, Michael J.& Sangani, Rahul G.. Emerging Risk Profile of Lung Cancer Therapy: Diffuse Alveolar Hemorrhage from Osimertinib. Case Reports in Oncological Medicine No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1142038

American Medical Association (AMA)

Forte, Michael J.& Sangani, Rahul G.. Emerging Risk Profile of Lung Cancer Therapy: Diffuse Alveolar Hemorrhage from Osimertinib. Case Reports in Oncological Medicine. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1142038

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1142038