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Cardioprotection Effects of Sevoflurane by Regulating the Pathway of Neuroactive Ligand-Receptor Interaction in Patients Undergoing Coronary Artery Bypass Graft Surgery
Joint Authors
Wang, Jinquan
Cheng, Jian
Zhang, Chao
Li, Xiaojun
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study was designed to identify attractor modules and further reveal the potential biological processes involving in sevoflurane-induced anesthesia in patients treated with coronary artery bypass graft (CABG) surgery.
Microarray profile data (ID: E-GEOD-4386) on atrial samples obtained from patients receiving anesthetic gas sevoflurane prior to and following CABG procedure were downloaded from EMBL-EBI database for further analysis.
Protein-protein interaction (PPI) networks of baseline and sevoflurane groups were inferred and reweighted according to Spearman correlation coefficient (SCC), followed by systematic modules inference using clique-merging approach.
Subsequently, attract method was utilized to explore attractor modules.
Finally, pathway enrichment analyses for genes in the attractor modules were implemented to illuminate the biological processes in sevoflurane group.
Using clique-merging approach, 27 and 36 modules were obtained from the PPI networks of baseline and sevoflurane-treated samples, respectively.
By comparing with the baseline condition, 5 module pairs with the same gene composition were identified.
Subsequently, 1 out of 5 modules was identified as an attractor based on attract method.
Additionally, pathway analysis indicated that genes in the attractor module were associated with neuroactive ligand-receptor interaction.
Accordingly, sevoflurane might exert important functions in cardioprotection in patients following CABG, partially through regulating the pathway of neuroactive ligand-receptor interaction.
American Psychological Association (APA)
Wang, Jinquan& Cheng, Jian& Zhang, Chao& Li, Xiaojun. 2017. Cardioprotection Effects of Sevoflurane by Regulating the Pathway of Neuroactive Ligand-Receptor Interaction in Patients Undergoing Coronary Artery Bypass Graft Surgery. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1142077
Modern Language Association (MLA)
Wang, Jinquan…[et al.]. Cardioprotection Effects of Sevoflurane by Regulating the Pathway of Neuroactive Ligand-Receptor Interaction in Patients Undergoing Coronary Artery Bypass Graft Surgery. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1142077
American Medical Association (AMA)
Wang, Jinquan& Cheng, Jian& Zhang, Chao& Li, Xiaojun. Cardioprotection Effects of Sevoflurane by Regulating the Pathway of Neuroactive Ligand-Receptor Interaction in Patients Undergoing Coronary Artery Bypass Graft Surgery. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1142077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142077