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Synchronous Ovarian and Breast Cancers with a Novel Variant in BRCA2 Gene: A Case Report
Joint Authors
Llinás-Quintero, Néstor
Cabrera-Florez, Eduardo
Mendoza-Fandiño, Gustavo
Matute-Turizo, Gustavo
Vasquez-Trespalacios, Elsa M.
Gallón-Villegas, Luis J.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We report a case of a 52-year-old female with a family history of pancreatic and colon cancers who presented with a right breast mass positive for high-grade medullar carcinoma with triple-negative biomolecular profile.
Further workup was performed finding a left ovarian mass.
The patient underwent laparotomy performing optimal cytoreduction on bilateral ovarian tumors; the pathology and immunohistochemistry confirmed bilateral ovary adenocarcinoma with positive peritoneal malignancy.
Due to her synchronic breast and ovarian cancers, a genetic profile was performed detecting a new pathogenic variant in the BRCA2 gene: c.3606_3607del (p.Ser1203Cysfs).
She was given chemotherapy with carboplatin and paclitaxel obtaining complete clinical response.
Regarding her breast cancer, she had a right modified radical mastectomy and prophylactic left mastectomy obtaining complete clinical response.
This case presents with an unusual subtype and difficult histologic diagnosis of a synchronic medullar breast cancer and ovary carcinoma associated with a new mutation of the BRCA2 gene.
American Psychological Association (APA)
Llinás-Quintero, Néstor& Cabrera-Florez, Eduardo& Mendoza-Fandiño, Gustavo& Matute-Turizo, Gustavo& Vasquez-Trespalacios, Elsa M.& Gallón-Villegas, Luis J.. 2019. Synchronous Ovarian and Breast Cancers with a Novel Variant in BRCA2 Gene: A Case Report. Case Reports in Oncological Medicine،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1142087
Modern Language Association (MLA)
Llinás-Quintero, Néstor…[et al.]. Synchronous Ovarian and Breast Cancers with a Novel Variant in BRCA2 Gene: A Case Report. Case Reports in Oncological Medicine No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1142087
American Medical Association (AMA)
Llinás-Quintero, Néstor& Cabrera-Florez, Eduardo& Mendoza-Fandiño, Gustavo& Matute-Turizo, Gustavo& Vasquez-Trespalacios, Elsa M.& Gallón-Villegas, Luis J.. Synchronous Ovarian and Breast Cancers with a Novel Variant in BRCA2 Gene: A Case Report. Case Reports in Oncological Medicine. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1142087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142087