Excellent Response to Nivolumab and Ipilimumab in Metastatic Gastroesophageal Junction Squamous Carcinoma
Joint Authors
Sadagopan, Narayanan
Devoe, Craig
Source
Case Reports in Oncological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-11
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Unresectable gastroesophageal junction (GEJ) cancers have a poor prognosis and limited treatment options.
We report the case of a patient with a Siewert class III gastroesophageal junction squamous carcinoma with metastatic spread into the liver who had an exceptional response to a combination therapy of nivolumab and ipilimumab despite being programmed death-ligand 1 (PD-L1) negative, microsatellite stable (MSS), and having a low tumor mutational burden.
He initially experienced disease progression on the chemotherapy regimens modified DCF and FOLFIRI resulting in limited functional status, esophageal stent placement, and feeding tube placement.
After about 6 months on nivolumab and ipilimumab, he had near-complete disease resolution.
He was able to return to his baseline functional status, as well as have the esophageal stent and feeding tube removed.
Our case contributes to the value of exploring immunotherapy as an option for a variety of hard to treat cancers.
American Psychological Association (APA)
Sadagopan, Narayanan& Devoe, Craig. 2019. Excellent Response to Nivolumab and Ipilimumab in Metastatic Gastroesophageal Junction Squamous Carcinoma. Case Reports in Oncological Medicine،Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1142091
Modern Language Association (MLA)
Sadagopan, Narayanan& Devoe, Craig. Excellent Response to Nivolumab and Ipilimumab in Metastatic Gastroesophageal Junction Squamous Carcinoma. Case Reports in Oncological Medicine No. 2019 (2019), pp.1-3.
https://search.emarefa.net/detail/BIM-1142091
American Medical Association (AMA)
Sadagopan, Narayanan& Devoe, Craig. Excellent Response to Nivolumab and Ipilimumab in Metastatic Gastroesophageal Junction Squamous Carcinoma. Case Reports in Oncological Medicine. 2019. Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1142091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142091