Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma
Joint Authors
Peterson, Richard A.
Kashyap, Bhavani
Pawloski, Pamala A.
Forsberg, Anna C.
Hanson, Leah R.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Radiation-induced sarcomas in the brain are extremely rare, usually occur with an average latency of 9 years, and are associated with poor outcomes.
Latency periods shorter than 1 year may indicate a genetic predisposition such as Li-Fraumeni syndrome.
A 34-year-old man underwent initial tumor resection and radiation therapy for a World Health Organization (WHO) Grade II Astrocytoma.
Within 6 months, the tumor recurred as WHO Grade III and was treated with temozolomide and then bevacizumab.
Despite the patient’s apparent improving condition, MRI revealed new dural-based lesions 10 months after radiation therapy and identified as high-grade sarcoma.
The patient resumed bevacizumab, began NovoTTF treatment for progressing glioma, and ifosfamide/doxorubicin for the sarcoma.
Genetic testing revealed no pathogenic mutation in the TP53 gene.
Ultimately, treatment was unsuccessful and the patient succumbed to glioma and sarcoma within 2 years of initial diagnosis.
This case was unique due to the rapidly progressing glioma and sudden appearance of a high-grade sarcoma.
It is unusual to have two separate intracranial primary cancers with each requiring a different chemotherapy regimen.
We discuss the difficulty of simultaneously treating with separate chemotherapy regimens.
It remains unclear whether the sarcoma was induced by the radiation treatment or a genetic predisposition.
American Psychological Association (APA)
Peterson, Richard A.& Kashyap, Bhavani& Pawloski, Pamala A.& Forsberg, Anna C.& Hanson, Leah R.. 2019. Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma. Case Reports in Oncological Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1142112
Modern Language Association (MLA)
Peterson, Richard A.…[et al.]. Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma. Case Reports in Oncological Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1142112
American Medical Association (AMA)
Peterson, Richard A.& Kashyap, Bhavani& Pawloski, Pamala A.& Forsberg, Anna C.& Hanson, Leah R.. Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma. Case Reports in Oncological Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1142112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142112