Topological Measurements of DWI Tractography for Alzheimer’s Disease Detection
Joint Authors
Tangaro, Sabina
Amoroso, Nicola
The Alzheimer's Disease Neuroimaging Initiative, Wenliang
Monaco, Alfonso
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neurodegenerative diseases affect brain morphology and connectivity, making complex networks a suitable tool to investigate and model their effects.
Because of its stereotyped pattern Alzheimer’s disease (AD) is a natural benchmark for the study of novel methodologies.
Several studies have investigated the network centrality and segregation changes induced by AD, especially with a single subject approach.
In this work, a holistic perspective based on the application of multiplex network concepts is introduced.
We define and assess a diagnostic score to characterize the brain topology and measure the disease effects on a mixed cohort of 52 normal controls (NC) and 47 AD patients, from Alzheimer’s Disease Neuroimaging Initiative (ADNI).
The proposed topological score allows an accurate NC-AD classification: the average area under the curve (AUC) is 95% and the 95% confidence interval is 92%–99%.
Besides, the combination of topological information and structural measures, such as the hippocampal volumes, was also investigated.
Topology is able to capture the disease signature of AD and, as the methodology is general, it can find interesting applications to enhance our insight into disease with more heterogeneous patterns.
American Psychological Association (APA)
Amoroso, Nicola& Monaco, Alfonso& Tangaro, Sabina& The Alzheimer's Disease Neuroimaging Initiative, Wenliang. 2017. Topological Measurements of DWI Tractography for Alzheimer’s Disease Detection. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1142184
Modern Language Association (MLA)
Amoroso, Nicola…[et al.]. Topological Measurements of DWI Tractography for Alzheimer’s Disease Detection. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1142184
American Medical Association (AMA)
Amoroso, Nicola& Monaco, Alfonso& Tangaro, Sabina& The Alzheimer's Disease Neuroimaging Initiative, Wenliang. Topological Measurements of DWI Tractography for Alzheimer’s Disease Detection. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1142184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142184