Complementary Keratoconus Indices Based on Topographical Interpretation of Biomechanical Waveform Parameters: A Supplement to Established Keratoconus Indices
Joint Authors
Langenbucher, Achim
Eppig, Timo
Wagenpfeil, Stefan
Cayless, Alan
Goebels, Susanne Christiane
Seitz, Berthold
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To build new models with the Ocular Response Analyzer (ORA) waveform parameters to create new indices analogous to established topographic keratoconus indices.
Method.
Biomechanical, tomographic, and topographic measurements of 505 eyes from the Homburger Keratoconus Centre were included.
Thirty-seven waveform parameters (WF) were derived from the biomechanical measurement with the ORA.
Area under curve (ROC, receiver operating characteristic) was used to quantify the screening performance.
A logistic regression analysis was used to create two new keratoconus prediction models based on these waveform parameters to resample the clinically established keratoconus indices from Pentacam and TMS-5.
Results.
ROC curves show the best results for the waveform parameters p1area, p2area, h1, h2, dive1, mslew1, aspect1, aplhf, and dslope1.
The new keratoconus prediction model to resample the Pentacam topographic keratoconus index (TKC) was WFTKC = −4.068 + 0.002 × p2area − 0.005 × dive1 − 0.01 × h1 − 2.501 × aplhf, which achieves a sensitivity of 90.3% and specificity of 89.4%; to resample the TMS-5 keratoconus classification index (KCI) it was WFKCI = −3.606 + 0.002 × p2area, which achieves a sensitivity of 75.4% and a specificity of 81.8%.
Conclusion.
In addition to the biomechanically provided Keratoconus Index two new indices which were based on the topographic gold standards (either Pentacam or TMS-5) were created.
Of course, these do not replace the original topographic measurement.
American Psychological Association (APA)
Goebels, Susanne Christiane& Eppig, Timo& Wagenpfeil, Stefan& Cayless, Alan& Seitz, Berthold& Langenbucher, Achim. 2017. Complementary Keratoconus Indices Based on Topographical Interpretation of Biomechanical Waveform Parameters: A Supplement to Established Keratoconus Indices. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1142194
Modern Language Association (MLA)
Goebels, Susanne Christiane…[et al.]. Complementary Keratoconus Indices Based on Topographical Interpretation of Biomechanical Waveform Parameters: A Supplement to Established Keratoconus Indices. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1142194
American Medical Association (AMA)
Goebels, Susanne Christiane& Eppig, Timo& Wagenpfeil, Stefan& Cayless, Alan& Seitz, Berthold& Langenbucher, Achim. Complementary Keratoconus Indices Based on Topographical Interpretation of Biomechanical Waveform Parameters: A Supplement to Established Keratoconus Indices. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1142194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142194