Successful Modified Therapy in a Patient with Probable Infection-Associated Hemophagocytic Lymphohistiocytosis
Joint Authors
Kay, Carl
Rendo, Matthew J.
Gonzales, Paul
Beganovic, Sead G.
Czader, Magdalena
Source
Case Reports in Oncological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hemophagocytic lymphohistiocytosis (HLH) is a rare, hyperinflammatory syndrome characterized by clinical signs and symptoms of extreme inflammation.
In adults, HLH is typically a complication of infections, autoimmune diseases, and malignancies.
While the disease is often fatal, classic management of HLH revolves around early diagnosis and initiation of protocolized therapy.
We present a case of a previously healthy 56-year-old female who developed distributive shock requiring intubation, vasopressors, and continuous venovenous hemofiltration.
In the setting of multiple infectious syndromes, severe cytopenias, and rising direct hyperbilirubinemia, her diagnosis of HLH was confirmed.
Therapy was initiated with dexamethasone and two doses of reduced-intensity etoposide based on the patient’s clinical course.
Over the next few weeks, she continued to improve on dexamethasone monotherapy and has maintained remission up to the present with complete resolution of her cytopenias and return of baseline renal function.
Our case highlights the variability in the management of probable infection-associated HLH (IHLH) with a good patient outcome.
We demonstrate the potential to treat IHLH with partial protocols and minimal chemotherapeutics.
American Psychological Association (APA)
Kay, Carl& Rendo, Matthew J.& Gonzales, Paul& Beganovic, Sead G.& Czader, Magdalena. 2019. Successful Modified Therapy in a Patient with Probable Infection-Associated Hemophagocytic Lymphohistiocytosis. Case Reports in Oncological Medicine،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1142232
Modern Language Association (MLA)
Kay, Carl…[et al.]. Successful Modified Therapy in a Patient with Probable Infection-Associated Hemophagocytic Lymphohistiocytosis. Case Reports in Oncological Medicine No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1142232
American Medical Association (AMA)
Kay, Carl& Rendo, Matthew J.& Gonzales, Paul& Beganovic, Sead G.& Czader, Magdalena. Successful Modified Therapy in a Patient with Probable Infection-Associated Hemophagocytic Lymphohistiocytosis. Case Reports in Oncological Medicine. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1142232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142232